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Park, Jongnam
Materials and Chemistry Lab (MCL)
Research Interests
  • Inorganic synthesis, microfluidics, nanomaterials, surface engineering, bioimaging

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Facile Synthetic Route for Surface-Functionalized Magnetic Nanoparticles: Cell Labeling and Magnetic Resonance Imaging Studies

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dc.contributor.author Chung, Hyun Jung ko
dc.contributor.author Lee, Haeshin ko
dc.contributor.author Bae, Ki Hyun ko
dc.contributor.author Lee, Yuhan ko
dc.contributor.author Park, Jongnam ko
dc.contributor.author Cho, Seung-Woo ko
dc.contributor.author Hwang, Jin Young ko
dc.contributor.author Park, Hyunwook ko
dc.contributor.author Langer, Robert ko
dc.contributor.author Anderson, Daniel ko
dc.contributor.author Park, Tae Gwan ko
dc.date.available 2014-04-10T02:15:24Z -
dc.date.created 2013-06-18 ko
dc.date.issued 2011-06 ko
dc.identifier.citation ACS NANO, v.5, no.6, pp.4329 - 4336 ko
dc.identifier.issn 1936-0851 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3606 -
dc.description.abstract Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH(2)), was the most effective dispersion agent. The 6(PEG-NH(2))-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenthymal stem cells and demonstrate MR contrast potential with high r(2) relaxivity (442.7 s(-1)mM(-1)) compared to the commercially available Feridex (182.1 s(-1)mM(-1)). ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Facile Synthetic Route for Surface-Functionalized Magnetic Nanoparticles: Cell Labeling and Magnetic Resonance Imaging Studies ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79959777306 ko
dc.identifier.wosid 000292055200012 ko
dc.type.rims ART ko
dc.description.scopustc 32 *
dc.date.scptcdate 2014-07-12 *
dc.identifier.doi 10.1021/nn201198f ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959777306 ko
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