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Kim, Young R.
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Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model

DC Field Value Language Huang, Shuning ko Kim, Jeong Kon ko Atochin, Dmitriy N. ko Farrar, Christian T. ko Huang, Paul L. ko Suh, Ji Yeon ko Kwon, Seon Joo ko Shim, Woo Hyun ko Cho, Hyungjoon ko Cho, Gyunggoo ko Kim, Young R. ko 2014-04-10T01:57:26Z - 2013-07-03 ko 2013-06 -
dc.identifier.citation JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.33, no.6, pp.898 - 905 ko
dc.identifier.issn 0271-678X ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Insufficient vascular reserve after an ischemic stroke may induce biochemical cascades that subsequently deteriorate the blood-brain barrier (BBB) function. However, the direct relationship between poor cerebral blood volume (CBV) restoration and BBB disruption has not been examined in acute stroke. To quantify BBB integrity at acute stages of transient stroke, in particular for cases in which extravasation of the standard contrast agent (Gd-DTPA) is not observed, we adopted the water exchange index (WEI), a novel magnetic resonance image-derived parameter to estimate the water permeability across the BBB. The apparent diffusion coefficient (ADC) and R 2 relaxation rate constant were also measured for outlining the tissue abnormality, while fractional CBV and WEI were quantified for assessing vascular alterations. The significantly decreased ADC and R 2 in the ischemic cortices did not correlate with the changes in CBV or WEI. In contrast, a strong negative correlation between the ipsilesional WEI and CBV was found, in which stroke mice were clustered into two groups: (1) high WEI and low CBV and (2) normal WEI and CBV. The low CBV observed for mice with a disrupted BBB, characterized by a high WEI, indicates the importance of CBV restoration for maintaining BBB stability in acute stroke. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.subject Blood-brain barrier ko
dc.subject Cerebral blood volume ko
dc.subject MRI ko
dc.subject Stroke ko
dc.subject Water exchange ko
dc.title Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84878571252 ko
dc.identifier.wosid 000319821100013 ko
dc.type.rims ART ko
dc.description.scopustc 0 * 2014-07-12 *
dc.identifier.doi 10.1038/jcbfm.2013.27 ko
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