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Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications


Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery

DC Field Value Language Lee, Sueun ko Saito, Kyohei ko Lee, Hye-Ra ko Lee, Min Jae ko Shibasaki, Yuji ko Oishi, Yoshiyuld ko Kim, Byeong-Su ko 2014-04-10T01:53:04Z - 2013-06-20 ko 2012-04 -
dc.identifier.citation BIOMACROMOLECULES, v.13, no.4, pp.1190 - 1196 ko
dc.identifier.issn 1525-7797 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a self-assembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pH-responsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject Anti-cancer agents ko
dc.subject Average size ko
dc.subject Controlled release ko
dc.subject Core-shell ko
dc.subject Double-hydrophilic block copolymers ko
dc.subject Doxorubicin ko
dc.subject Drug delivery system ko
dc.subject Drug release ko
dc.subject Drug-loading efficiency ko
dc.subject Efficient drug delivery ko
dc.subject Enhanced efficiency ko
dc.subject Ethylene oxides ko
dc.subject Hydrazone bonds ko
dc.subject Hyperbranched ko
dc.subject In-vitro ko
dc.subject Micellar structures ko
dc.subject pH sensitive ko
dc.subject PH-responsive ko
dc.subject Polyglycerols ko
dc.subject Self-assembled ko
dc.subject Stimuli-responsive ko
dc.subject Water solubilities ko
dc.title Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84860726945 ko
dc.identifier.wosid 000303076200029 ko
dc.type.rims ART ko
dc.description.scopustc 28 * 2014-07-12 *
dc.identifier.doi 10.1021/bm300151m ko
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