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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Kim, Jung-Min | - |
dc.contributor.author | Shin, Hong-In | - |
dc.contributor.author | Cha, Sun-Shin | - |
dc.contributor.author | Lee, Chang Sup | - |
dc.contributor.author | Hong, Bok Sil | - |
dc.contributor.author | Lim, Seyoung | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Yun, Sanguk | - |
dc.contributor.author | Rijal, Girdhari | - |
dc.contributor.author | Lee-Kwon, Whaseon | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Gho, Yong Song | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Hur, Eun-Mi | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T04:36:52Z | - |
dc.date.available | 2023-12-22T04:36:52Z | - |
dc.date.created | 2013-07-01 | - |
dc.date.issued | 2012-12 | - |
dc.description.abstract | Communication between osteoblasts and endothelial cells is essential for bone fracture repair, but the molecular identities of such communicating factors are not well defined. Here we identify DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells through an unbiased screening of molecules secreted from human mesenchymal stem cells during osteogenesis. We show that DJ-1 stimulates the differentiation of human mesenchymal stem cells to osteoblasts and that DJ-1 induces angiogenesis in endothelial cells through activation of fibroblast growth factor receptor-1 signalling. In a rodent model of bone fracture repair, extracellular application of DJ-1 enhances bone regeneration in vivo by stimulating the formation of blood vessels and new bones. Both these effects are blocked by antagonizing fibroblast growth factor receptor-1 signalling. These findings uncover previously undefined extracellular roles of DJ-1 to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.3, pp.1 - 11 | - |
dc.identifier.doi | 10.1038/ncomms2313 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-84871775091 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3402 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871775091 | - |
dc.identifier.wosid | 000316356700063 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-4 | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DEFECT MODEL | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAYS | - |
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