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DC Field | Value | Language |
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dc.citation.endPage | 545 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 535 | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 20 | - |
dc.contributor.author | Prabagar, M. G. | - |
dc.contributor.author | Do, Yoonkyung | - |
dc.contributor.author | Ryu, S. | - |
dc.contributor.author | Park, J-Y | - |
dc.contributor.author | Choi, H-J | - |
dc.contributor.author | Choi, W-S | - |
dc.contributor.author | Yun, T. J. | - |
dc.contributor.author | Moon, J. | - |
dc.contributor.author | Choi, I-S | - |
dc.contributor.author | Ko, K. | - |
dc.contributor.author | Shin, C. Young | - |
dc.contributor.author | Cheong, C. | - |
dc.contributor.author | Kang, Y-S | - |
dc.date.accessioned | 2023-12-22T04:08:40Z | - |
dc.date.available | 2023-12-22T04:08:40Z | - |
dc.date.created | 2013-06-28 | - |
dc.date.issued | 2013-04 | - |
dc.description.abstract | Complements, such as C1q and C3, and macrophages in the splenic marginal zone (MZMs) play pivotal roles in the efficient uptake and processing of circulating apoptotic cells. SIGN-R1, a C-type lectin that is highly expressed in a subpopulation of MZMs, regulates the complement fixation pathway by interacting with C1q, to fight blood-borne Streptococcus pneumoniae. Therefore, we examined whether the SIGN-R1-mediated classical complement pathway plays a role in apoptotic cell clearance and immune tolerance. SIGN-R1 first-bound apoptotic cells and this binding was significantly enhanced in the presence of C1q. SIGN-R1-C1q complex then immediately mediated C3 deposition on circulating apoptotic cells in the MZ, leading to the efficient clearance of them. SIGN-R1-mediated C3 deposition was completely abolished in the spleen of SIGN-R1 knockout (KO) mice. Given that SIGN-R1 is not expressed in the liver, we were struck by the finding that C3-deposited apoptotic cells were still found in the liver of wild-type mice, and dramatically reduced in the SIGN-R1 KO liver. In particular, SIGN-R1 deficiency caused delayed clearance of apoptotic cells and aberrant secretion of cytokines, such as TNF-alpha, IL-6, and TGF-beta in the spleen as well as in the liver. In addition, anti-double-and single-stranded DNA antibody level was significantly increased in SIGN-R1-depleted mice compared with control mice. These findings suggest a novel mechanism of apoptotic cell clearance which is initiated by SIGN-R1 in the MZ and identify an integrated role of SIGN-R1 in the systemic clearance of apoptotic cells, linking the recognition of apoptotic cells, the opsonization of complements, and the induction of immune tolerance. | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.20, no.4, pp.535 - 545 | - |
dc.identifier.doi | 10.1038/cdd.2012.160 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.scopusid | 2-s2.0-84874948249 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3382 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874948249 | - |
dc.identifier.wosid | 000317264600002 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | SIGN-R1 | - |
dc.subject.keywordAuthor | splenic marginal zone macrophages | - |
dc.subject.keywordAuthor | complements | - |
dc.subject.keywordAuthor | apoptotic cells | - |
dc.subject.keywordAuthor | autoimmune disease | - |
dc.subject.keywordPlus | MARGINAL ZONE MACROPHAGES | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | MARROW-DERIVED MACROPHAGES | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | MEDIATES UPTAKE | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | RECEPTORS | - |
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