There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 317 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 312 | - |
dc.citation.title | JOURNAL OF LIPID RESEARCH | - |
dc.citation.volume | 60 | - |
dc.contributor.author | Ratti, Stefano | - |
dc.contributor.author | Follo, Matilde Y. | - |
dc.contributor.author | Ramazzotti, Giulia | - |
dc.contributor.author | Faenza, Irene | - |
dc.contributor.author | Fiume, Roberta | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | McCubrey, James A. | - |
dc.contributor.author | Manzoli, Lucia | - |
dc.contributor.author | Cocco, Lucio | - |
dc.date.accessioned | 2023-12-21T19:37:58Z | - |
dc.date.available | 2023-12-21T19:37:58Z | - |
dc.date.created | 2019-02-22 | - |
dc.date.issued | 2019-02 | - |
dc.description.abstract | Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways related to critical cellular functions, such as cell cycle regulation, cell differentiation, and gene expression. Nuclear PI-PLCs have been studied as key enzymes, molecular targets, and clinical prognostic/diagnostic factors in many physiopathologic processes. Here, we summarize the main studies about nuclear PI-PLCs, specifically, the imbalance of isozymes such as PI-PLC beta 1 and PI-PLC zeta, in cerebral, hematologic, neuromuscular, and fertility disorders. PI-PLC beta 1 and PI-PLC gamma 1 affect epilepsy, depression, and bipolar disorder. In the brain, PI-PLC beta 1 is involved in endocannabinoid neuronal excitability and is a potentially novel signature gene for subtypes of high-grade glioma. An altered quality or quantity of PI-PLC zeta contributes to sperm defects that result in infertility, and PI-PLC beta 1 aberrant inositide signaling contributes to both hematologic and degenerative muscle diseases. Understanding the mechanisms behind PI-PLC involvement in human pathologies may help identify new strategies for personalized therapies of these conditions. | - |
dc.identifier.bibliographicCitation | JOURNAL OF LIPID RESEARCH, v.60, no.2, pp.312 - 317 | - |
dc.identifier.doi | 10.1194/jlr.R089763 | - |
dc.identifier.issn | 0022-2275 | - |
dc.identifier.scopusid | 2-s2.0-85060944723 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/33050 | - |
dc.identifier.url | http://www.jlr.org/content/60/2/312 | - |
dc.identifier.wosid | 000458212900009 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Nuclear phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular, and fertility disorders[S] | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | nucleus | - |
dc.subject.keywordAuthor | myelodysplastic syndromes | - |
dc.subject.keywordAuthor | fertility | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | brain | - |
dc.subject.keywordAuthor | myotonic dystrophy | - |
dc.subject.keywordPlus | DIACYLGLYCEROL KINASE | - |
dc.subject.keywordPlus | ERYTHROID-DIFFERENTIATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | PLC-ZETA | - |
dc.subject.keywordPlus | BETA-1 | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | AZACITIDINE | - |
dc.subject.keywordPlus | C-BETA-1 | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.