Full metadata record
DC Field | Value | Language |
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dc.citation.number | 9 | - |
dc.citation.startPage | 3198 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Lee, Eun-Soo | - |
dc.contributor.author | Ahn, Yujin | - |
dc.contributor.author | Bae, Il-Hong | - |
dc.contributor.author | Min, Daejin | - |
dc.contributor.author | Park, Nok Hyun | - |
dc.contributor.author | Jung, Woonggyu | - |
dc.contributor.author | Kim, Se-Hwa | - |
dc.contributor.author | Hong, Yong Deog | - |
dc.contributor.author | Park, Won Seok | - |
dc.contributor.author | Lee, Chang Seok | - |
dc.date.accessioned | 2023-12-21T17:38:07Z | - |
dc.date.available | 2023-12-21T17:38:07Z | - |
dc.date.created | 2020-06-18 | - |
dc.date.issued | 2020-05 | - |
dc.description.abstract | The outer epidermal skin is a primary barrier that protects the body from extrinsic factors, such as ultraviolet (UV) radiation, chemicals and pollutants. The complete epithelialization of a wound by keratinocytes is essential for restoring the barrier function of the skin. However, age-related alterations predispose the elderly to impaired wound healing. Therefore, wound-healing efficacy could be also considered as a potent function of an anti-aging reagent. Here, we examine the epidermal wound-healing efficacy of the fourth-generation retinoid, seletinoid G, using HaCaT keratinocytes and skin tissues. We found that seletinoid G promoted the proliferation and migration of keratinocytes in scratch assays and time-lapse imaging. It also increased the gene expression levels of several keratinocyte proliferation-regulating factors. In human skin equivalents, seletinoid G accelerated epidermal wound closure, as assessed using optical coherence tomography (OCT) imaging. Moreover, second harmonic generation (SHG) imaging revealed that seletinoid G recovered the reduced dermal collagen deposition seen in ultraviolet B (UVB)-irradiated human skin equivalents. Taken together, these results indicate that seletinoid G protects the skin barrier by accelerating wound healing in the epidermis and by repairing collagen deficiency in the dermis. Thus, seletinoid G could be a potent anti-aging agent for protecting the skin barrier. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.9, pp.3198 | - |
dc.identifier.doi | 10.3390/ijms21093198 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.scopusid | 2-s2.0-85084032946 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/32390 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/21/9/3198 | - |
dc.identifier.wosid | 000535581700169 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | seletinoid G | - |
dc.subject.keywordAuthor | wound healing | - |
dc.subject.keywordAuthor | keratinocyte | - |
dc.subject.keywordAuthor | human skin equivalents | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordAuthor | second harmonic generation | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | REPAIR | - |
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