Full metadata record
DC Field | Value | Language |
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dc.citation.number | 4 | - |
dc.citation.startPage | 249 | - |
dc.citation.title | DIAGNOSTICS | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Kim, Hyera | - |
dc.contributor.author | Lim, Minji | - |
dc.contributor.author | Kim, Jin Young | - |
dc.contributor.author | Shin, So-Jin | - |
dc.contributor.author | Cho, Yoon-Kyoung | - |
dc.contributor.author | Cho, Chi Heum | - |
dc.date.accessioned | 2023-12-21T17:41:14Z | - |
dc.date.available | 2023-12-21T17:41:14Z | - |
dc.date.created | 2020-06-08 | - |
dc.date.issued | 2020-04 | - |
dc.description.abstract | We investigated the size-based isolation and enumeration of circulating tumor cells (CTCs) using a centrifugal microfluidic device equipped with a fluid-assisted separation technology (FAST) disc. We further assessed the correlations among CTCs, cancer antigen-125 (CA125) levels, and clinical course of the disease in a prospective analysis of 47 serial blood samples collected at multiple time-points from 13 ovarian cancer patients. CTCs were isolated from whole blood using the FAST disc and were classified as epithelial cell adhesion molecule (EpCAM)/cytokeratin+, CD45-, and 4 ',6-diamidino-2-phenylindole (DAPI)+. Mean CTC count at baseline was 20.2; 84.62% of patients had more than one CTC at baseline and had decreased CTCs counts after surgery and chemotherapy. The CTC counts in eight patients with complete responses were <3. CTC counts were correlated with CA125 levels in three patients without recurrence; they were elevated in three patients with recurrence and normal CA125 concentrations. CTC counts and CA125 levels showed high concordance with directional changes (increasing 71.4%; non-increasing 75.0%). CTC counts showed higher associations with clinical status, sensitivity (100.0% vs. 60.0%), positive predictive value (55.6% vs. 42.9%), and negative predictive value (100.0% vs. 87.5%) than CA125 levels. CTC counts were better associated with treatment response and recurrence than CA125 levels. | - |
dc.identifier.bibliographicCitation | DIAGNOSTICS, v.10, no.4, pp.249 | - |
dc.identifier.doi | 10.3390/diagnostics10040249 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.scopusid | 2-s2.0-85083848463 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/32373 | - |
dc.identifier.url | https://www.mdpi.com/2075-4418/10/4/249 | - |
dc.identifier.wosid | 000534251000022 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | Circulating Tumor Cells Enumerated by a Centrifugal Microfluidic Device as a Predictive Marker for Monitoring Ovarian Cancer Treatment: A Pilot Study | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | ovarian cancer | - |
dc.subject.keywordAuthor | circulating tumor cells | - |
dc.subject.keywordAuthor | fluid-assisted separation technology | - |
dc.subject.keywordAuthor | centrifugal microfluidic device | - |
dc.subject.keywordAuthor | CA125 | - |
dc.subject.keywordPlus | EPITHELIAL OVARIAN | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CA-125 | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | CTCS | - |
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