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Suh, Pann-Ghill
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dc.citation.endPage 1013 -
dc.citation.number 5 -
dc.citation.startPage 1004 -
dc.citation.title MOLECULAR THERAPY -
dc.citation.volume 21 -
dc.contributor.author Lee, Yu Jin -
dc.contributor.author Kim, Il Shin -
dc.contributor.author Park, Soo-Ah -
dc.contributor.author Kim, Youndong -
dc.contributor.author Lee, Jeung Eun -
dc.contributor.author Noh, Dong-Young -
dc.contributor.author Kim, Kyong-Tai -
dc.contributor.author Ryu, Sung Ho -
dc.contributor.author Suh, Pann-Ghill -
dc.date.accessioned 2023-12-22T04:07:13Z -
dc.date.available 2023-12-22T04:07:13Z -
dc.date.created 2013-07-04 -
dc.date.issued 2013-05 -
dc.description.abstract Periostin is an extracellular matrix (ECM) protein that is overexpressed in a variety of human cancers, and its functions appear to be linked to tumor growth, metastasis, and angiogenesis. Recent clinical evidence suggests that aberrant periostin expression is correlated with poor outcome in patients with breast cancer. To identify novel tools to regulate the functional role of periostin, we generated benzyl-d(U)TP-modified DNA aptamers that were directed against human periostin (PNDAs) and characterized their functional roles in breast cancer progression. PNDA-3 selectively bound to the FAS-1 domain of periostin with nanomolar affinity and disrupted the interaction between periostin and its cell surface receptors, alpha(v)beta(3) and alpha(v)beta(5) integrins. PNDA-3 markedly antagonized the periostin-induced adhesion, migration, and invasion of breast cancer cells and blocked the activation of various components of the alpha(v)beta(3) and alpha(v)beta(5) integrin signal transduction pathways. In a 4T1 orthotopic mouse model, PNDA-3 administration significantly reduced primary tumor growth and distant metastasis. Thus, our results demonstrated that periostin-integrin signaling regulates breast cancer progression at multiple levels in tumor cells and the tumor microenvironment. DNA aptamers targeting periostin may potentially be used to inhibit breast cancer progression. -
dc.identifier.bibliographicCitation MOLECULAR THERAPY, v.21, no.5, pp.1004 - 1013 -
dc.identifier.doi 10.1038/mt.2013.30 -
dc.identifier.issn 1525-0016 -
dc.identifier.scopusid 2-s2.0-84877079933 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3159 -
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1525001616306803?via%3Dihub -
dc.identifier.wosid 000318334800012 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Periostin-binding DNA Aptamer Inhibits Breast Cancer Growth and Metastasis -
dc.type Article -
dc.relation.journalWebOfScienceCategory Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental -
dc.relation.journalResearchArea Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus CELL-SURVIVAL -
dc.subject.keywordPlus EXPONENTIAL ENRICHMENT -
dc.subject.keywordPlus SYSTEMATIC EVOLUTION -
dc.subject.keywordPlus BONE METASTASES -
dc.subject.keywordPlus AKT/PKB PATHWAY -
dc.subject.keywordPlus TUMOR-GROWTH -
dc.subject.keywordPlus LUNG-CANCER -
dc.subject.keywordPlus TENASCIN-C -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus ANTIBODY -

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