File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

TlustyTsvi

Tlusty, Tsvi
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.number 8 -
dc.citation.startPage e0118129 -
dc.citation.title PLOS ONE -
dc.citation.volume 8 -
dc.contributor.author Friedlander, Tamar -
dc.contributor.author Mayo, Avraham E. -
dc.contributor.author Tlusty, Tsvi -
dc.contributor.author Alon, Uri -
dc.date.accessioned 2023-12-22T03:38:58Z -
dc.date.available 2023-12-22T03:38:58Z -
dc.date.created 2020-02-20 -
dc.date.issued 2013-08 -
dc.description.abstract Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually occur; and modularity - the near decomposability of the system into modules with distinct functionality. Recent work suggests that modularity can evolve in a variety of circumstances, including goals that vary in time such that they share the same subgoals (modularly varying goals), or when connections are costly. Here, we studied the origin of modularity and sparseness focusing on the nature of the mutation process, rather than on connection cost or variations in the goal. We use simulations of evolution with different mutation rules. We found that commonly used sum-rule mutations, in which interactions are mutated by adding random numbers, do not lead to modularity or sparseness except for in special situations. In contrast, product-rule mutations in which interactions are mutated by multiplying by random numbers - a better model for the effects of biological mutations - led to sparseness naturally. When the goals of evolution are modular, in the sense that specific groups of inputs affect specific groups of outputs, product-rule mutations also lead to modular structure; sum-rule mutations do not. Product-rule mutations generate sparseness and modularity because they tend to reduce interactions, and to keep small interaction terms small. -
dc.identifier.bibliographicCitation PLOS ONE, v.8, no.8, pp.e0118129 -
dc.identifier.doi 10.1371/journal.pone.0070444 -
dc.identifier.issn 1932-6203 -
dc.identifier.scopusid 2-s2.0-84881145372 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/31173 -
dc.identifier.url https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070444 -
dc.identifier.wosid 000324401500036 -
dc.language 영어 -
dc.publisher PUBLIC LIBRARY SCIENCE -
dc.title Mutation Rules and the Evolution of Sparseness and Modularity in Biological Systems -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus GENE NETWORKS -
dc.subject.keywordPlus MODEL -
dc.subject.keywordPlus ENVIRONMENTS -
dc.subject.keywordPlus PLASTICITY -
dc.subject.keywordPlus EMERGENCE -
dc.subject.keywordPlus SHAPES -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.