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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1242 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1235 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 5 | - |
dc.contributor.author | Hugues, S | - |
dc.contributor.author | Fetler, L | - |
dc.contributor.author | Bonifaz, L | - |
dc.contributor.author | Helft, J | - |
dc.contributor.author | Amblard, F | - |
dc.contributor.author | Amigorena, S | - |
dc.date.accessioned | 2023-12-22T10:40:16Z | - |
dc.date.available | 2023-12-22T10:40:16Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2004-12 | - |
dc.description.abstract | Induction of immunity and peripheral tolerance requires contacts between antigen-bearing dendritic cells (DCs) and cognate T cells. Using real-time two-photon microscopy, we have analyzed the dynamics of CD8(+) T cells in lymph nodes during the induction of antigen-specific immunity or tolerance. At 15-20 h after the induction of immunity, T cells stopped moving and established prolonged interactions with DCs. In tolerogenic conditions, despite effective initial T cell activation and proliferation, naive T cells remained motile and established serial brief contacts with multiple DCs. Thus, stable DC-T cell interactions occur during the induction of priming, whereas brief contacts may contribute to the induction of T cell tolerance. | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.5, no.12, pp.1235 - 1242 | - |
dc.identifier.doi | 10.1038/ni1134 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.scopusid | 2-s2.0-16544383331 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31084 | - |
dc.identifier.url | https://www.nature.com/articles/ni1134 | - |
dc.identifier.wosid | 000225353500012 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | DEC-205 | - |
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