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DC Field | Value | Language |
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dc.citation.endPage | 108 | - |
dc.citation.startPage | 63 | - |
dc.citation.title | INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 295 | - |
dc.citation.volume | 295 | - |
dc.contributor.author | de Beco, Simon | - |
dc.contributor.author | Amblard, Francois | - |
dc.contributor.author | Coscoy, Sylvie | - |
dc.date.accessioned | 2023-12-22T04:36:19Z | - |
dc.date.available | 2023-12-22T04:36:19Z | - |
dc.date.created | 2020-01-31 | - |
dc.date.issued | 2012-20 | - |
dc.description.abstract | Homeostasis of adherens junctions is achieved through complex regulatory mechanisms. The junctions are highly dynamic in contact establishment, in remodeling events during development, and during processes involving a loss of adhesion like epithelial mesenchyme transition. It appeared recently that they are also dynamically renewed in mature, steady-state adhesions. Indeed, maintenance of a steady state must be integrated into a tight control of force equilibrium between a cell and its neighbors. Therefore, it appears that E-cadherin dynamics allows to respond constantly to various biochemical and mechanical stimuli and to regulate the movement and shape of junctions in active remodeling processes. E-cadherin dynamics is mediated through several mechanisms (diffusion, trafficking) in function of the biological system. In mature junctions, membrane E-cadherin is quickly renewed by endocytosis in many cell types. E-cadherin endocytosis shows a complex regulation, depending on small G proteins, ubiquitination, cleavage events, actomyosin cytoskeleton, and other trans molecules in adherens junctions. It is modulated by growth factor stimulations and physical factors. Consequently, E-cadherin endocytosis tightly controls a number of functional processes: cell movements, junction maintenance, cell sorting, and polarity. Misregulated E-cadherin endocytosis is involved in many diseases, from cancerous processes to organogenesis defects. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 295, v.295, pp.63 - 108 | - |
dc.identifier.doi | 10.1016/B978-0-12-394306-4.00008-3 | - |
dc.identifier.issn | 1937-6448 | - |
dc.identifier.scopusid | 2-s2.0-84858841358 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/31036 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/B9780123943064000083?via%3Dihub | - |
dc.identifier.wosid | 000303626600002 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER ACADEMIC PRESS INC | - |
dc.title | NEW INSIGHTS INTO THE REGULATION OF E-CADHERIN DISTRIBUTION BY ENDOCYTOSIS | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Review; Book Chapter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | homeostasis | - |
dc.subject.keywordAuthor | Adherens junction | - |
dc.subject.keywordAuthor | E-cadherin | - |
dc.subject.keywordAuthor | Endocytosis | - |
dc.subject.keywordPlus | CELL-CELL-ADHESION | - |
dc.subject.keywordPlus | FLUORESCENCE PHOTOBLEACHING RECOVERY | - |
dc.subject.keywordPlus | CLATHRIN-MEDIATED ENDOCYTOSIS | - |
dc.subject.keywordPlus | MAMMALIAN EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | SINGLE-PARTICLE TRACKING | - |
dc.subject.keywordPlus | SMALL G-PROTEINS | - |
dc.subject.keywordPlus | ADHERENS JUNCTIONS | - |
dc.subject.keywordPlus | P120 CATENIN | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | N-CADHERIN | - |
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