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DC Field | Value | Language |
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dc.citation.number | 11 | - |
dc.citation.startPage | 1802115 | - |
dc.citation.title | ADVANCED SCIENCE | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Jeun, Minhong | - |
dc.contributor.author | Lee, Hyo Jeong | - |
dc.contributor.author | Park, Sungwook | - |
dc.contributor.author | Do, Eun‐ju | - |
dc.contributor.author | Choi, Jaewon | - |
dc.contributor.author | Sung, You‐Na | - |
dc.contributor.author | Hong, Seung‐Mo | - |
dc.contributor.author | Kim, Sang‐Yeob | - |
dc.contributor.author | Kim, Dong‐Hee | - |
dc.contributor.author | Kang, Ja Young | - |
dc.contributor.author | Son, Hye‐Nam | - |
dc.contributor.author | Joo, Jinmyoung | - |
dc.contributor.author | Song, Eun Mi | - |
dc.contributor.author | Hwang, Sung Wook | - |
dc.contributor.author | Park, Sang Hyoung | - |
dc.contributor.author | Yang, Dong‐Hoon | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.contributor.author | Byeon, Jeong‐Sik | - |
dc.contributor.author | Choe, Jaewon | - |
dc.contributor.author | Yang, Suk‐Kyun | - |
dc.contributor.author | Moinova, Helen | - |
dc.contributor.author | Markowitz, Sanford D. | - |
dc.contributor.author | Lee, Kwan Hyi | - |
dc.contributor.author | Myung, Seung‐Jae | - |
dc.date.accessioned | 2023-12-21T19:06:51Z | - |
dc.date.available | 2023-12-21T19:06:51Z | - |
dc.date.created | 2020-01-14 | - |
dc.date.issued | 2019-06 | - |
dc.description.abstract | Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein-2 (CCSP-2) is a promising blood marker for CRC. An electric-field effect colorectal sensor (E-FECS), an ion-sensitive field-effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP-2 directly from patient blood samples. The sensing performance of the E-FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP-2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP 2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E-FECS system successfully detects CCSP-2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP-2 has potential for use as a blood-based biomarker for CRC. | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, v.6, no.11, pp.1802115 | - |
dc.identifier.doi | 10.1002/advs.201802115 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.scopusid | 2-s2.0-85064602319 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30791 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201802115 | - |
dc.identifier.wosid | 000470189500015 | - |
dc.language | 영어 | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.title | A Novel Blood‐Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein‐2 | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | colorectal adenomas | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | colorectal cancer screening | - |
dc.subject.keywordAuthor | electric-field effect colorectal sensor | - |
dc.subject.keywordAuthor | tumor markers | - |
dc.subject.keywordPlus | COLONOSCOPY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | RATES | - |
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