There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 115538 | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 229 | - |
dc.contributor.author | Kim, Mirae | - |
dc.contributor.author | Ahn, Yujin | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Jung, Woonggyu | - |
dc.contributor.author | Cha, Chaenyung | - |
dc.date.accessioned | 2023-12-21T18:07:46Z | - |
dc.date.available | 2023-12-21T18:07:46Z | - |
dc.date.created | 2019-12-12 | - |
dc.date.issued | 2020-02 | - |
dc.description.abstract | In situ forming hydrogels generated upon spontaneous and biocompatible reaction under physiological conditions are widely investigated as injectable and implantable biomaterials. However, it is still a significant challenge to control their mechanics while maintaining their gelation behavior, due to the interdependency between gelation kinetics and mechanics. Herein, physicomechanical properties of in situ forming chitosan hydrogels via Schiff base formation are tuned in a wide range, while maintaining gelation kinetics, via polymer graft architecture. By introducing poly(ethylene glycol) (PEG) grafts with varying lengths and densities, the resulting PEG-grafted chitosan (‘PEG-g-Cs’) not only dissolve readily in neutral aqueous media, but also effectively control the mechanical properties of hydrogels, while maintaining facile gelation kinetics. These properties are further controlled by the chain length of polymeric crosslinker, PEG-dialdehyde. In addition, tissue adhesive properties of the hydrogels are further examined using ex vivo and in vivo models for their potential applications as tissue sealants. | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.229, pp.115538 | - |
dc.identifier.doi | 10.1016/j.carbpol.2019.115538 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.scopusid | 2-s2.0-85075539473 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30634 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0144861719312068 | - |
dc.identifier.wosid | 000501796600065 | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | In situ facile-forming chitosan hydrogels with tunable physicomechanical and tissue adhesive properties by polymer graft architecture | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied; Chemistry, Organic; Polymer Science | - |
dc.relation.journalResearchArea | Chemistry; Polymer Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | PEG-g-chitosan | - |
dc.subject.keywordAuthor | in situ forming hydrogel | - |
dc.subject.keywordAuthor | Schiff base | - |
dc.subject.keywordAuthor | mechanics | - |
dc.subject.keywordAuthor | gelation kine | - |
dc.subject.keywordAuthor | ticstissue sealant | - |
dc.subject.keywordPlus | INJECTABLE HYDROGELS | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | RHEOLOGICAL CHARACTERIZATION | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | DEGRADATION BEHAVIOR | - |
dc.subject.keywordPlus | PEG HYDROGELS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | DELIVERY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.