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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 551 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 539 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 25 | - |
dc.contributor.author | Lee, Mi Nam | - |
dc.contributor.author | Koh, Ara | - |
dc.contributor.author | Park, Dohyun | - |
dc.contributor.author | Jang, Jin-Hyeok | - |
dc.contributor.author | Kwak, Dongoh | - |
dc.contributor.author | Jeon, Hyeona | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Choi, Eun-Jeong | - |
dc.contributor.author | Jeong, Heeyoon | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.date.accessioned | 2023-12-22T04:13:48Z | - |
dc.date.available | 2023-12-22T04:13:48Z | - |
dc.date.created | 2013-06-12 | - |
dc.date.issued | 2013-02 | - |
dc.description.abstract | Ras homolog enriched in brain (Rheb) regulates diverse cellular functions by modulating its nucleotide-bound status. Although Rheb contains a high basal GTP level, the regulatory mechanism of Rheb is not well understood. In this study, we propose soluble alpha beta-tubulin acts as a constitutively active Rheb activator, which may explain the reason why Rheb has a high basal GTP levels. We found that soluble alpha beta-tubulin is a direct Rheb-binding protein and that its deacetylated form has a high binding affinity for Rheb. Modulation of both soluble and acetylated alpha beta-tubulin levels affects the level of GTP-bound Rheb. This occurs in the mitotic phase in which the level of acetylated alpha beta-tubulin is increased but that of GTP-bound Rheb is decreased. Constitutively active Rheb-overexpressing cells showed an abnormal mitotic progression, suggesting the deacetylated alpha beta-tubulin-mediated regulation of Rheb status may be important for proper mitotic progression. Taken together, we propose that deacetylated soluble alpha beta-tubulin is a novel type of positive regulator of Rheb and may play a role as a temporal regulator for Rheb during the cell cycle. | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.25, no.2, pp.539 - 551 | - |
dc.identifier.doi | 10.1016/j.cellsig.2012.11.006 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.scopusid | 2-s2.0-84875122960 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/3061 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875122960 | - |
dc.identifier.wosid | 000313921100016 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Deacetylated alpha beta-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Rheb | - |
dc.subject.keywordAuthor | Soluble tubulin | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | Mitosis | - |
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