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- Kwon, Taejoon
- TaejoonLab
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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 7976 | - |
| dc.citation.number | 24 | - |
| dc.citation.startPage | 7972 | - |
| dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
| dc.citation.volume | 58 | - |
| dc.contributor.author | Kim, Beomsue | - |
| dc.contributor.author | Fukuda, Masahiro | - |
| dc.contributor.author | Lee, Jung-Yeol | - |
| dc.contributor.author | Su, Dongdong | - |
| dc.contributor.author | Sanu, Srikanta | - |
| dc.contributor.author | Silvin, Aymeric | - |
| dc.contributor.author | Khoo, Audrey T. T. | - |
| dc.contributor.author | Kwon, Taejoon | - |
| dc.contributor.author | Liu, Xiao | - |
| dc.contributor.author | Chi, Weijie | - |
| dc.contributor.author | Liu, Xiaogang | - |
| dc.contributor.author | Choi, Sejong | - |
| dc.contributor.author | Wan, Diana S. Y. | - |
| dc.contributor.author | Park, Sung-Jin | - |
| dc.contributor.author | Kim, Jin-Soo | - |
| dc.contributor.author | Ginhoux, Florent | - |
| dc.contributor.author | Je, H. Shawn | - |
| dc.contributor.author | Chang, Young-Tae | - |
| dc.date.accessioned | 2023-12-21T19:07:01Z | - |
| dc.date.available | 2023-12-21T19:07:01Z | - |
| dc.date.created | 2019-07-26 | - |
| dc.date.issued | 2019-06 | - |
| dc.description.abstract | Microglia, the brain-resident macrophage, are involved in brain development and contribute to the progression of neural disorders. Despite the importance of microglia, imaging of live microglia at a cellular resolution has been limited to transgenic mice. Efforts have therefore been dedicated to developing new methods for microglia detection and imaging. Using a thorough structure-activity relationships study, we developed CDr20, a high-performance fluorogenic chemical probe that enables the visualization of microglia both in vitro and in vivo. Using a genome-scale CRISPR-Cas9 knockout screen, the UDP-glucuronosyltransferase Ugt1a7c was identified as the target of CDr20. The glucuronidation of CDr20 by Ugt1a7c in microglia produces fluorescence. | - |
| dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.58, no.24, pp.7972 - 7976 | - |
| dc.identifier.doi | 10.1002/anie.201903058 | - |
| dc.identifier.issn | 1433-7851 | - |
| dc.identifier.scopusid | 2-s2.0-85065170767 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30404 | - |
| dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201903058 | - |
| dc.identifier.wosid | 000474117600005 | - |
| dc.language | 영어 | - |
| dc.publisher | WILEY-V C H VERLAG GMBH | - |
| dc.title | Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate | - |
| dc.type | Article | - |
| dc.description.isOpenAccess | FALSE | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.type.docType | Article | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordAuthor | biological activity | - |
| dc.subject.keywordAuthor | fluorescent probes | - |
| dc.subject.keywordAuthor | imaging agents | - |
| dc.subject.keywordAuthor | microglia | - |
| dc.subject.keywordAuthor | structure-activity relationships | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | TRANSCRIPTOME | - |
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