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DC Field | Value | Language |
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dc.citation.endPage | 1080 | - |
dc.citation.startPage | 1069 | - |
dc.citation.title | APPLIED SURFACE SCIENCE | - |
dc.citation.volume | 483 | - |
dc.contributor.author | Na, Hee-Kyung | - |
dc.contributor.author | Kim, Hyunhong | - |
dc.contributor.author | Son, Jin Gyeong | - |
dc.contributor.author | Lee, Ji Hong | - |
dc.contributor.author | Kim, Jeong-Kwon | - |
dc.contributor.author | Park, Jongnam | - |
dc.contributor.author | Lee, Tae Geol | - |
dc.date.accessioned | 2023-12-21T19:06:32Z | - |
dc.date.available | 2023-12-21T19:06:32Z | - |
dc.date.created | 2019-05-03 | - |
dc.date.issued | 2019-07 | - |
dc.description.abstract | Appropriate surface designs and precise characterizations of nanoparticles (NPs) are important but as of yet unrealized in biomedical applications of nanomaterials. We report a facile synthetic approach to the preparation of iron oxide (Fe 3 O 4 ) NPs with different surface charges through exchange with polymeric ligands. An accurate analysis method for characterization of the surface-modified Fe 3 O 4 NPs using a combination of the time-of-flight secondary ion mass spectrometry (ToF-SIMS) and Fourier transform infrared spectroscopy (FT-IR) techniques is demonstrated. A comparison of the spatial distribution of the ligand and core particles with ToF-SIMS and FT-IR verified the successful modification and purification. In addition, the surface was shown to play an important role in interactions with live cells in terms of cytotoxicity, cellular uptake, and even gene transfection. Interestingly, precise control over the surface chemistry of NP enabled efficient transfection of siRNA into suspension type cell, the Jurkat human leukemic T cell line, achieving successful down regulation of NOTCH1 whose signaling pathway is known to be involved in acute leukemia. Our report presents an in-depth study of the interactions between the NPs and cells, as well as their synthesis, characterization, and surface-dependent performance properties. | - |
dc.identifier.bibliographicCitation | APPLIED SURFACE SCIENCE, v.483, pp.1069 - 1080 | - |
dc.identifier.doi | 10.1016/j.apsusc.2019.04.059 | - |
dc.identifier.issn | 0169-4332 | - |
dc.identifier.scopusid | 2-s2.0-85064078795 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30400 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0169433219310517?via%3Dihub | - |
dc.identifier.wosid | 000471105000119 | - |
dc.language | 영어 | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Facile synthesis and direct characterization of surface-charge-controlled magnetic iron oxide nanoparticles and their role in gene transfection in human leukemic T cell | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter | - |
dc.relation.journalResearchArea | Chemistry; Materials Science; Physics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Characterization of surface coated material | - |
dc.subject.keywordAuthor | Chemical information of nanoparticle surface | - |
dc.subject.keywordAuthor | Surface modification | - |
dc.subject.keywordAuthor | Transfection of suspension cell | - |
dc.subject.keywordPlus | Cell culture | - |
dc.subject.keywordPlus | Chemical modification | - |
dc.subject.keywordPlus | Coated materials | - |
dc.subject.keywordPlus | Fourier transform infrared spectroscopy | - |
dc.subject.keywordPlus | Genes | - |
dc.subject.keywordPlus | Iron oxides | - |
dc.subject.keywordPlus | Ligands | - |
dc.subject.keywordPlus | Magnetite | - |
dc.subject.keywordPlus | Medical applications | - |
dc.subject.keywordPlus | Molecular biology | - |
dc.subject.keywordPlus | Nanomagnetics | - |
dc.subject.keywordPlus | Nanoparticles | - |
dc.subject.keywordPlus | Organic polymers | - |
dc.subject.keywordPlus | Secondary ion mass spectrometry | - |
dc.subject.keywordPlus | Surface charge | - |
dc.subject.keywordPlus | Surface chemistry | - |
dc.subject.keywordPlus | Surface treatment | - |
dc.subject.keywordPlus | Synthesis (chemical) | - |
dc.subject.keywordPlus | T-cells | - |
dc.subject.keywordPlus | Biomedical applications | - |
dc.subject.keywordPlus | Fourier transform infra red (FTIR) spectroscopy | - |
dc.subject.keywordPlus | Magnetic iron oxide nanoparticles | - |
dc.subject.keywordPlus | Nanoparticle surface | - |
dc.subject.keywordPlus | Performance properties | - |
dc.subject.keywordPlus | Surface coated | - |
dc.subject.keywordPlus | Suspension cell | - |
dc.subject.keywordPlus | Time of flight secondary ion mass spectrometry | - |
dc.subject.keywordPlus | Cell signaling | - |
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