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DC Field | Value | Language |
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dc.citation.endPage | 1386.e11 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1375 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 178 | - |
dc.contributor.author | Gong, Jianke | - |
dc.contributor.author | Liu, Jinzhi | - |
dc.contributor.author | Ronan, Elizabeth A. | - |
dc.contributor.author | He, Feiteng | - |
dc.contributor.author | Cai, Wei | - |
dc.contributor.author | Fatima, Mahar | - |
dc.contributor.author | Zhang, Wenyuan | - |
dc.contributor.author | Lee, Hankyu | - |
dc.contributor.author | Li, Zhaoyu | - |
dc.contributor.author | Kim, Gun-Ho | - |
dc.contributor.author | Pipe, Kevin P. | - |
dc.contributor.author | Duan, Bo | - |
dc.contributor.author | Liu, Jianfeng | - |
dc.contributor.author | Xu, X. Z. Shawn | - |
dc.date.accessioned | 2023-12-21T18:42:25Z | - |
dc.date.available | 2023-12-21T18:42:25Z | - |
dc.date.created | 2019-09-19 | - |
dc.date.issued | 2019-09 | - |
dc.description.abstract | In search of the molecular identities of cold-sensing receptors, we carried out an unbiased genetic screen for cold-sensing mutants in C. elegans and isolated a mutant allele of glr-3 gene that encodes a kainate-type glutamate receptor. While glutamate receptors are best known to transmit chemical synaptic signals in the CNS, we show that GLR-3 senses cold in the peripheral sensory neuron ASER to trigger cold-avoidance behavior. GLR-3 transmits cold signals via G protein signaling independently of its glutamate-gated channel function, suggesting GLR-3 as a metabotropic cold receptor. The vertebrate GLR-3 homolog GluK2 from zebrafish, mouse, and human can all function as a cold receptor in heterologous systems. Mouse DRG sensory neurons ex- prc GluK2, and GluK2 knockdown in these neurons suppresses their sensitivity to cold but not cool temperatures. Our study identifies an evolutionarily conserved cold receptor, revealing that a central chemical receptor unexpectedly functions as a thermal receptor in the periphery. | - |
dc.identifier.bibliographicCitation | CELL, v.178, no.6, pp.1375 - 1386.e11 | - |
dc.identifier.doi | 10.1016/j.cell.2019.07.034 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-85071609663 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/30371 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0092867419308335?via%3Dihub | - |
dc.identifier.wosid | 000483983000013 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | C.-ELEGANS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | NOCICEPTIVE NEURONS | - |
dc.subject.keywordPlus | TRP CHANNEL | - |
dc.subject.keywordPlus | KAINATE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | AMPA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SENSATION | - |
dc.subject.keywordPlus | SUBUNITS | - |
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