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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells

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dc.contributor.author Kim, Jung-Min ko
dc.contributor.author Choi, Jin Seok ko
dc.contributor.author Kim, Yun-Hee ko
dc.contributor.author Jin, Seong Hui ko
dc.contributor.author Lim, Seyoung ko
dc.contributor.author Jang, Hyun-Jun ko
dc.contributor.author Kim, Kyong-Tai ko
dc.contributor.author Ryu, Sung Ho ko
dc.contributor.author Suh, Pann-Ghill ko
dc.date.available 2014-04-10T01:18:19Z -
dc.date.created 2013-06-10 ko
dc.date.issued 2013-03 ko
dc.identifier.citation JOURNAL OF CELLULAR PHYSIOLOGY, v.228, no.3, pp.617 - 626 ko
dc.identifier.issn 0021-9541 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/2958 -
dc.description.abstract Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell-based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazolepyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone-related diseases and for the study of bone biology. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-BLACKWELL ko
dc.title An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84870449303 ko
dc.identifier.wosid 000311912900015 ko
dc.type.rims ART ko
dc.description.wostc 8 *
dc.description.scopustc 6 *
dc.date.tcdate 2015-02-28 *
dc.date.scptcdate 2014-08-25 *
dc.identifier.doi 10.1002/jcp.24171 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870449303 ko
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