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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 626 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 617 | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 228 | - |
dc.contributor.author | Kim, Jung-Min | - |
dc.contributor.author | Choi, Jin Seok | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Jin, Seong Hui | - |
dc.contributor.author | Lim, Seyoung | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T04:11:14Z | - |
dc.date.available | 2023-12-22T04:11:14Z | - |
dc.date.created | 2013-06-10 | - |
dc.date.issued | 2013-03 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) are multipotent adult stem cells capable of differentiating along the osteoblast, adipocyte, and chondrocyte lineages. Regulation of MSCs differentiation may be a useful tool for regenerative medicine and cell-based therapy. The discovery of small molecule that activates the osteogenic differentiation of MSCs could aid in the development of a new anabolic drug for osteoporosis treatment. We identified CW008, a derivative of pyrazolepyridine, that stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. These results suggest that CW008 is an agonist of cAMP/PKA/CREB pathway in osteogenic differentiation and that application of CW008 may be useful for the treatment of bone-related diseases and for the study of bone biology. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.228, no.3, pp.617 - 626 | - |
dc.identifier.doi | 10.1002/jcp.24171 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.scopusid | 2-s2.0-84870449303 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2958 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870449303 | - |
dc.identifier.wosid | 000311912900015 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Cell Biology; Physiology | - |
dc.relation.journalResearchArea | Cell Biology; Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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