There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1161 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1153 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 22 | - |
dc.contributor.author | Choi, Jung Woong | - |
dc.contributor.author | Lim, Seyoung | - |
dc.contributor.author | Oh, Yong-Seok | - |
dc.contributor.author | Kim, Eung-Kyun | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Heo, Kyun | - |
dc.contributor.author | Kim, Jaeyoon | - |
dc.contributor.author | Kim, Jung Kuk | - |
dc.contributor.author | Yang, Yong Ryul | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T07:07:29Z | - |
dc.date.available | 2023-12-22T07:07:29Z | - |
dc.date.created | 2013-06-07 | - |
dc.date.issued | 2010-07 | - |
dc.description.abstract | Among phospholipase C (PLC) isozymes (beta, gamma, delta, epsilon, zeta and eta), PLC-beta plays a key role in G-protein coupled receptor (GPCR)-mediated signaling. PLC-beta subtypes are often overlapped in their distribution, but have unique knock-out phenotypes in organism, suggesting that each subtype may have the different role even within the same type of cells. In this study, we examined the possibility of the differential coupling of each PLC-beta subtype to GPCRs, and explored the molecular mechanism underlying the specificity. Firstly, we found that PLC-beta 1 and PLC-beta 3 are activated by bradykinin (BK) or lysophosphatidic acid (LPA), respectively. BK-triggered phosphoinositides hydrolysis and subsequent Ca(2+) mobilization were abolished specifically by PLC-beta 1 silencing, whereas LPA-triggered events were by PLC-beta 3 silencing. Secondly, we showed the evidence that PDZ scaffold proteins is a key mediator for the selective coupling between PLC-beta subtype and GPCR. We found PAR-3 mediates physical interaction between PLC-beta 1 and BK receptor, while NHERF2 does between PLC-beta 3 and LPA(2) receptor. Consistently, the silencing of PAR-3 or NHERF2 blunted PLC signaling induced by BK or LPA respectively. Taken together, these data suggest that each subtype of PLC-beta is selectively coupled to GPCR via PDZ scaffold proteins in given cell types and plays differential role in the signaling of various GPCRs. | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.22, no.7, pp.1153 - 1161 | - |
dc.identifier.doi | 10.1016/j.cellsig.2010.03.010 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.scopusid | 2-s2.0-77952290357 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2939 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952290357 | - |
dc.identifier.wosid | 000278258600018 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Subtype-specific role of phospholipase C-beta in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.