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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


Involvement of exercise-induced macrophage migration inhibitory factor in the prevention of fatty liver disease

DC Field Value Language Moon, Hyo Youl ko Song, Parkyong ko Choi, Cheol Soo ko Ryu, Sung Ho ko Suh, Pann-Ghill ko 2014-04-10T00:25:56Z - 2013-08-27 ko 2013-08 ko
dc.identifier.citation JOURNAL OF ENDOCRINOLOGY, v.218, no.3, pp.339 - 348 ko
dc.identifier.issn 0022-0795 ko
dc.identifier.uri -
dc.description.abstract Physical inactivity can lead to obesity and fat accumulation in various tissues. Critical complications of obesity include type II diabetes and nonalcoholic fatty liver disease (NAFLD). Exercise has been reported to have ameliorating effects on obesity and NAFLD. However, the underlying mechanism is not fully understood. We showed that liver expression of macrophage migration inhibitory factor (MIF) was increased after 4 weeks of treadmill exercise. Phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase in human hepatocyte cell lines was enhanced after MIF treatment. These responses were accompanied by increases in lipid oxidation. Moreover, inhibition of eitherAMPKor cluster of differentiation 74 resulted in inhibition of MIF-induced lipid oxidation. Furthermore, the administration of MIF to a human hepatocyte cell line and mice liver reduced liver X receptor agonist-induced lipid accumulation. Taken together, these results indicate that MIF is highly expressed in the liver during physical exercise and may prevent hepatic steatosis by activating the AMPK pathway. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher BIOSCIENTIFICA LTD ko
dc.title Involvement of exercise-induced macrophage migration inhibitory factor in the prevention of fatty liver disease ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84884172693 ko
dc.identifier.wosid 000319860502341 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 * 2015-02-28 * 2014-08-25 *
dc.identifier.doi 10.1530/JOE-13-0135 ko
dc.identifier.url ko
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