BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Involvement of exercise-induced macrophage migration inhibitory factor in the prevention of fatty liver disease

DC Field Value Language
dc.contributor.author Moon, Hyo Youl ko
dc.contributor.author Song, Parkyong ko
dc.contributor.author Choi, Cheol Soo ko
dc.contributor.author Ryu, Sung Ho ko
dc.contributor.author Suh, Pann-Ghill ko
dc.date.available 2014-04-10T00:25:56Z -
dc.date.created 2013-08-27 ko
dc.date.issued 2013-08 ko
dc.identifier.citation JOURNAL OF ENDOCRINOLOGY, v.218, no.3, pp.339 - 348 ko
dc.identifier.issn 0022-0795 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/2847 -
dc.description.abstract Physical inactivity can lead to obesity and fat accumulation in various tissues. Critical complications of obesity include type II diabetes and nonalcoholic fatty liver disease (NAFLD). Exercise has been reported to have ameliorating effects on obesity and NAFLD. However, the underlying mechanism is not fully understood. We showed that liver expression of macrophage migration inhibitory factor (MIF) was increased after 4 weeks of treadmill exercise. Phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase in human hepatocyte cell lines was enhanced after MIF treatment. These responses were accompanied by increases in lipid oxidation. Moreover, inhibition of eitherAMPKor cluster of differentiation 74 resulted in inhibition of MIF-induced lipid oxidation. Furthermore, the administration of MIF to a human hepatocyte cell line and mice liver reduced liver X receptor agonist-induced lipid accumulation. Taken together, these results indicate that MIF is highly expressed in the liver during physical exercise and may prevent hepatic steatosis by activating the AMPK pathway. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher BIOSCIENTIFICA LTD ko
dc.title Involvement of exercise-induced macrophage migration inhibitory factor in the prevention of fatty liver disease ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84884172693 ko
dc.identifier.wosid 000319860502341 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-02-28 *
dc.date.scptcdate 2014-08-25 *
dc.identifier.doi 10.1530/JOE-13-0135 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884172693 ko
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show simple item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU