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Min, Duyoung
Single-molecule Biophysics and Biochemistry Lab
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dc.citation.startPage 5654 -
dc.citation.title NATURE COMMUNICATIONS -
dc.citation.volume 5 - Bae, Wooli - Kim, Kipom - Min, Duyoung - Ryu, Je-Kyung - Hyeon, Changbong - Yoon, Tae-Young - 2023-12-22T01:46:23Z - 2023-12-22T01:46:23Z - 2019-10-04 - 2014-12 -
dc.description.abstract Despite the recent development in the design of DNA origami, its folding yet relies on thermal or chemical annealing methods. We here demonstrate mechanical folding of the DNA origami structure via a pathway that has not been accessible to thermal annealing. Using magnetic tweezers, we stretch a single scaffold DNA with mechanical tension to remove its secondary structures, followed by base pairing of the stretched DNA with staple strands. When the force is subsequently quenched, folding of the DNA nanostructure is completed through displacement between the bound staple strands. Each process in the mechanical folding is well defined and free from kinetic traps, enabling us to complete folding within 10 min. We also demonstrate parallel folding of DNA nanostructures through multiplexed manipulation of the scaffold DNAs. Our results suggest a path towards programmability of the folding pathway of DNA nanostructures. -
dc.identifier.bibliographicCitation NATURE COMMUNICATIONS, v.5, pp.5654 -
dc.identifier.doi 10.1038/ncomms6654 -
dc.identifier.issn 2041-1723 -
dc.identifier.scopusid 2-s2.0-84922719573 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000347227700004 -
dc.language 영어 -
dc.title Programmed folding of DNA origami structures through single-molecule force control -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus NANOSCALE SHAPES -
dc.subject.keywordPlus NANOSTRUCTURES -
dc.subject.keywordPlus KINETICS -
dc.subject.keywordPlus FRET -
dc.subject.keywordPlus RNA -
dc.subject.keywordPlus REAL-TIME OBSERVATION -
dc.subject.keywordPlus MAGNETIC TWEEZERS -


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