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Author

Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics

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Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

Cited 48 times inthomson ciCited 44 times inthomson ci
Title
Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model
Author
Douville, Nicholas J.Zamankhan, ParsaTung, Yi-ChungLi, RanVaughan, Benjamin L.Tai, Cheng-FengWhite, JoshuaChristensen, Paul J.Grotberg, James B.Takayama, Shuichi
Keywords
RESPIRATORY-DISTRESS-SYNDROME; DEFORMATION-INDUCED INJURY; PARTIAL LIQUID VENTILATION; LINED FLEXIBLE TUBES; EPITHELIAL-CELLS; IN-VITRO; ELASTIC INSTABILITIES; AIRWAY-CLOSURE; LUNG INJURY; SURFACTANT
Issue Date
201102
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.4, pp.609 - 619
Abstract
Studies using this micro-system demonstrated significant morphological differences between alveolar epithelial cells (transformed human alveolar epithelial cell line, A549 and primary murine alveolar epithelial cells, AECs) exposed to combination of solid mechanical and surface-tension stresses (cyclic propagation of air-liquid interface and wall stretch) compared to cell populations exposed solely to cyclic stretch. We have also measured significant differences in both cell death and cell detachment rates in cell monolayers experiencing combination of stresses. This research describes new tools for studying the combined effects of fluid mechanical and solid mechanical stress on alveolar cells. It also highlights the role that surface tension forces may play in the development of clinical pathology, especially under conditions of surfactant dysfunction. The results support the need for further research and improved understanding on techniques to reduce and eliminate fluid stresses in clinical settings
URI
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DOI
http://dx.doi.org/10.1039/c0lc00251h
ISSN
1473-0197
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