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Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics
  • Bio-Nanotechnology
  • Biofluids
  • Biomaterials
  • Tissue Engineering and Regenerative Medicine.


High-density fabrication of normally closed microfluidic valves by patterned deactivation of oxidized polydimethylsiloxane

DC Field Value Language Mosadegh, Bobak ko Tavana, Hossein ko Lesher-Perez, Sasha Cai ko Takayama, Shuichi ko 2014-04-09T08:36:00Z - 2013-06-19 ko 2011-02 ko
dc.identifier.citation LAB ON A CHIP, v.11, no.4, pp.738 - 742 ko
dc.identifier.issn 1473-0197 ko
dc.identifier.uri -
dc.description.abstract The use of polydimethylsiloxane (PDMS) in microfluidic devices is extensive in academic research. One of the most fundamental treatments is to expose PDMS to plasma oxidation in order to render its surface temporarily hydrophilic and capable of permanent bonding. Here, we show that changes in the surface chemistry induced by plasma oxidation can spatially be counteracted very cleanly and reliably in a scalable manner by subsequent microcontact printing of residual oligomers from a PDMS stamp. We characterize the surface modifications through contact angle, atomic force microscopy, X-ray photoelectron spectroscopy, and bond-strength measurements. We utilize this approach for negating the bonding of a flexible membrane layer within an elastomeric valve and demonstrate its effectiveness by integration of over one thousand normally closed elastomeric valves within a single substrate. In addition, we demonstrate that surface energy patterning can be used for "open microfluidic" applications that utilize spatial control of surface wetting ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ROYAL SOC CHEMISTRY ko
dc.title High-density fabrication of normally closed microfluidic valves by patterned deactivation of oxidized polydimethylsiloxane ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79551625865 ko
dc.identifier.wosid 000286765700024 ko
dc.type.rims ART ko
dc.description.wostc 19 *
dc.description.scopustc 17 * 2015-02-28 * 2014-07-12 *
dc.identifier.doi 10.1039/c0lc00112k ko
dc.identifier.url!divAbstract ko
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