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DC Field | Value | Language |
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dc.citation.endPage | 8783 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 8766 | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 13 | - |
dc.contributor.author | Lin, Yuxi | - |
dc.contributor.author | Sahoo, Bikash R. | - |
dc.contributor.author | Ozawa, Daisaku | - |
dc.contributor.author | Kinoshita, Misaki | - |
dc.contributor.author | Kang, Juhye | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.contributor.author | Okumura, Masaki | - |
dc.contributor.author | Huh, Yang Hoon | - |
dc.contributor.author | Moon, Eunyoung | - |
dc.contributor.author | Jang, Jae Hyuck | - |
dc.contributor.author | Lee, Hyun-Ju | - |
dc.contributor.author | Ryu, Ka-Young | - |
dc.contributor.author | Ham, Sihyun | - |
dc.contributor.author | Wong, Haing-Sik | - |
dc.contributor.author | Ryu, Kyoung-Seok | - |
dc.contributor.author | Sugiki, Toshihiko | - |
dc.contributor.author | Bang, Jeong Kyu | - |
dc.contributor.author | Hoe, Hyang-Sook | - |
dc.contributor.author | Fujiwara, Toshimichi | - |
dc.contributor.author | Ramamoorthy, Ayyalusamy | - |
dc.contributor.author | Lee, Young-Ho | - |
dc.date.accessioned | 2023-12-21T18:49:01Z | - |
dc.date.available | 2023-12-21T18:49:01Z | - |
dc.date.created | 2019-09-19 | - |
dc.date.issued | 2019-08 | - |
dc.description.abstract | Complex amyloid aggregation of amyloid-beta (1-40) (A beta(1-40)) in terms of monomer structures has not been fully understood. Herein, we report the microscopic mechanism and pathways of A beta(1-40) aggregation with macroscopic viewpoints through tuning its initial structure and solubility. Partial helical structures of A beta(1-40) induced by low solvent polarity accelerated cytotoxic A beta(1-40) amyloid fibrillation, while predominantly helical folds did not aggregate. Changes in the solvent polarity caused a rapid formation of beta-structure-rich protofibrils or oligomers via aggregation-prone helical structures. Modulation of the pH and salt concentration transformed oligomers to protofibrils, which proceeded to amyloid formation. We reveal diverse molecular mechanisms underlying A beta(1-40) aggregation with conceptual energy diagrams and propose that aggregation-prone partial helical structures are key to inducing amyloidogenesis. We demonstrate that context-dependent protein aggregation is comprehensively understood using the macroscopic phase diagram, which provides general insights into differentiation of amyloid formation and phase separation from unfolded and folded structures. | - |
dc.identifier.bibliographicCitation | ACS NANO, v.13, no.8, pp.8766 - 8783 | - |
dc.identifier.doi | 10.1021/acsnano.9b01578 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.scopusid | 2-s2.0-85071712775 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/27518 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsnano.9b01578 | - |
dc.identifier.wosid | 000484077800027 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-beta (1-40) | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid beta | - |
dc.subject.keywordAuthor | amyloid fibril | - |
dc.subject.keywordAuthor | protein misfolding and aggregation | - |
dc.subject.keywordAuthor | aggregation pathway | - |
dc.subject.keywordAuthor | helical structure | - |
dc.subject.keywordAuthor | phase diagram | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | HELICAL INTERMEDIATE | - |
dc.subject.keywordPlus | CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | MUTATIONS ALTER | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | STATE | - |
dc.subject.keywordPlus | OLIGOMERS | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
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