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Author

Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic SERS platform

Cited 17 times inthomson ciCited 14 times inthomson ci
Title
In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic SERS platform
Author
Hwang, HyundooHan, DongsikOh, Young-JaeCho, Yoon-KyoungJeong, Ki-HunPark, Je-Kyun
Keywords
RAMAN-SPECTROSCOPY; SCATTERING; TWEEZERS; MICROPARTICLES; NANOPARTICLES; MANIPULATION; SYSTEM; CELLS; FLUID; CHIP
Issue Date
201104
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.11, no.15, pp.2518 - 2525
Abstract
A novel active surface-enhanced Raman scattering (SERS) platform for dynamic on-demand generation of SERS active sites based on optoelectrofluidics is presented in this paper. When a laser source is projected into a sample solution containing metal nanoparticles in an optoelectrofluidic device and an alternating current (ac) electric field is applied, the metal nanoparticles are spontaneously concentrated and assembled within the laser spot, form SERS-active sites, and enhance the Raman signal significantly, allowing dynamic and more sensitive SERS detection. In this simple platform, in which a glass slide-like optoelectrofluidic device is integrated into a conventional SERS detection system, both dynamic concentration of metal nanoparticles and in situ detection of SERS signal are simultaneously possible with only a single laser source. This optoelectrofluidic SERS spectroscopy allows on-demand generation of 'hot spots' at specific regions of interest, and highly sensitive, reliable, and stable SERS measurements of the target molecules in a tiny volume (similar to 500 nL) of liquid sample without any fluidic components and complicated systems.
URI
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DOI
http://dx.doi.org/10.1039/c1lc20277d
ISSN
1473-0197
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