Snake fang-inspired stamping patch for transdermal delivery of liquid formulations

DC Field Value Language Bae, Won-Gyu ko Ko, Hangil ko So, Jin-Young ko Yi, Hoon ko Lee, Chan-Ho ko Lee, Dong-Hun ko Ahn, Yujin ko Lee, Sang-Hyeon ko Lee, Kyunghun ko Jun, Joonha ko Kim, Hyoung-Ho ko Jeon, Noo Li ko Jung, Woonggyu ko Song, Chang-Seon ko Kim, Taesung ko Kim, Yeu-Chun ko Jeong, Hoon Eui ko 2019-09-16T08:05:43Z - 2019-08-23 ko 2019-07 ko
dc.identifier.citation SCIENCE TRANSLATIONAL MEDICINE, v.11, no.503, pp.eaaw3329 ko
dc.identifier.issn 1946-6234 ko
dc.identifier.uri -
dc.description.abstract A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang-inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (< 15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang-inspired open groove architectures enable rapid capillary force-driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang-inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice. ko
dc.language 영어 ko
dc.title Snake fang-inspired stamping patch for transdermal delivery of liquid formulations ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85070614386 ko
dc.identifier.wosid 000479139500002 ko
dc.type.rims ART ko
dc.identifier.doi 10.1126/scitranslmed.aaw3329 ko
dc.identifier.url ko
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