Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 2041731419 | - |
dc.citation.title | JOURNAL OF TISSUE ENGINEERING | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Han, Jonghyeuk | - |
dc.contributor.author | Kim, Da Sol | - |
dc.contributor.author | Jang, Il Ho | - |
dc.contributor.author | Kim, Hyung-Ryong | - |
dc.contributor.author | Kang, Hyun-Wook | - |
dc.date.accessioned | 2023-12-21T19:09:32Z | - |
dc.date.available | 2023-12-21T19:09:32Z | - |
dc.date.created | 2019-06-20 | - |
dc.date.issued | 2019-05 | - |
dc.description.abstract | Numerous approaches have been introduced to regenerate artificial dental tissues. However, conventional approaches are limited when producing a construct with three-dimensional patient-specific shapes and compositions of heterogeneous dental tissue. In this research, bioprinting technology was applied to produce a three-dimensional dentin-pulp complex with patient-specific shapes by inducing localized differentiation of human dental pulp stem cells within a single structure. A fibrin-based bio-ink was designed for bioprinting with the human dental pulp stem cells. The effects of fibrinogen concentration within the bio-ink were investigated in terms of printability, human dental pulp stem cell compatibility, and differentiation. The results show that micro-patterns with human dental pulp stem cells could be achieved with more than 88% viability. Its odontogenic differentiation was also regulated according to the fibrinogen concentration. Based on these results, a dentin-pulp complex having patient-specific shape was produced by co-printing the human dental pulp stem cell-laden bio-inks with polycaprolactone, which is a bio-thermoplastic used for producing the overall shape. After culturing with differentiation medium for 15 days, localized differentiation of human dental pulp stem cells in the outer region of the three-dimensional cellular construct was successfully achieved with localized mineralization. This result demonstrates the possibility to produce patient-specific composite tissues for tooth tissue engineering using three-dimensional bioprinting technology. | - |
dc.identifier.bibliographicCitation | JOURNAL OF TISSUE ENGINEERING, v.10, pp.2041731419 | - |
dc.identifier.doi | 10.1177/2041731419845849 | - |
dc.identifier.issn | 2041-7314 | - |
dc.identifier.scopusid | 2-s2.0-85067640395 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/26878 | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/2041731419845849 | - |
dc.identifier.wosid | 000470290000001 | - |
dc.language | 영어 | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Bioprinting of three-dimensional dentin-pulp complex with local differentiation of human dental pulp stem cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Bioprinting | - |
dc.subject.keywordAuthor | stem cells | - |
dc.subject.keywordAuthor | cell differentiation | - |
dc.subject.keywordAuthor | dentin | - |
dc.subject.keywordAuthor | dental pulp | - |
dc.subject.keywordAuthor | tissue engineering | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | SYSTEM | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.