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Rohde, Jan-Uwe
Transition Metal Chemistry
Research Interests
  • Inorganic chemistry, coordination chemistry, organometallic chemistry, chemical synthesis, catalysis, green chemistry, inorganic reaction mechanisms.


Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability

DC Field Value Language Maiti, Saikat ko Kim, Jaeshin ko Park, Jae-Heon ko Nam, Dongsik ko Lee, Jae Bin ko Kim, Ye Jin ko Kee, Jung-Min ko Seo, Jeong Kon ko Myung, Kyungjae ko Rohde, Jan-Uwe ko Choe, Wonyoung ko Kwon, Oh Hoon ko Hong, Sung You ko 2019-07-10T09:21:44Z - 2019-05-05 ko 2019-06 ko
dc.identifier.citation JOURNAL OF ORGANIC CHEMISTRY, v.84, no.11, pp.6737 - 6751 ko
dc.identifier.issn 0022-3263 ko
dc.identifier.uri -
dc.description.abstract Herein, we report chemoselective trifluoroethylation routes of unmasked 2-arylquinazolin-4(3H)-ones using mesityl(2,2,2-trifluoroethyl)iodonium triflate at room temperature. Homologous C-, O-, and N-functionalized subclasses are accessed in a straightforward manner with a wide substrate scope. These chemoselective branching events are driven by Pd-catalyzed ortho-selective C–H activation at the pendant aryl ring and base-promoted reactivity modulation of the amide group, leveraging the intrinsic directing capability and competing pronucleophilicity of the quinazolin-4(3H)-one framework. Furthermore, outstanding photostability of the quinazolin-4(3H)-one family associated with nonradiative decay is presented. ko
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85066127191 ko
dc.identifier.wosid 000471212000019 ko
dc.type.rims ART ko
dc.identifier.doi 10.1021/acs.joc.9b00470 ko
dc.identifier.url ko
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