File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher


Kim, Donghyuk
Systems Biology and Machine Learning Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 4210 -
dc.citation.number 9 -
dc.citation.startPage 4200 -
dc.citation.volume 99 - Kwon, Jeong Eun - Lim, Jaewon - Bang, Ina - Kim, Inhye - Kim, Donghyuk - Kang, Se Chan - 2023-12-21T19:06:31Z - 2023-12-21T19:06:31Z - 2019-05-09 - 2019-07 -
dc.description.abstract BACKGROUND: Equol is a major isoflavone metabolite, and equol-producing bacteria have been isolated and characterized; however, fermentation has been performed with soybean-based products as substrates. Pueraria lobata has been reported as a plant with higher content of isoflavones. RESULTS: The genome of new equol-producing bacteria, Lactobacillus paracasei JS1, was analyzed. Also, the effect of P.lobata extract fermented with L.paracasei JS1 (FPE) on the skin and intestinal immune response was examined. With gene expression analysis, it was proven that seven skin-related proteins, hyaluronan synthase-1, -2, -3, collagen, elastin, epidermal growth factor, and epidermal growth factor receptor were differentially expressed upon FPE treatment. The messenger RNA expression increased with treatment with the FPE, and a skin moisturizing effect was confirmed by a hematoxylin–eosin staining experiment. In addition, such an experiment showed that proinflammatory cytokines, tumor necrosis factor-α, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1β, -4, and -6, were reduced in large intestine when treated with FPE. CONCLUSION: L.paracasei JS1 has the ability to produce equol having beneficial effects on the skin. Moreover, FPE also has an inhibitory effect on inflammation cytokines in the large intestine. Thus, the novel and edible equol-producing L.paracasei JS1 and FPE have thepotential to be developed as nutricosmetic resources. -
dc.identifier.bibliographicCitation JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, v.99, no.9, pp.4200 - 4210 -
dc.identifier.doi 10.1002/jsfa.9648 -
dc.identifier.issn 0022-5142 -
dc.identifier.scopusid 2-s2.0-85064552305 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000479004900002 -
dc.language 영어 -
dc.publisher John Wiley and Sons Ltd -
dc.title Fermentation product with new equol-producing Lactobacillus paracasei as a probiotic-like product candidate for prevention of skin and intestinal disorder -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology -
dc.relation.journalResearchArea Agriculture; Chemistry; Food Science & Technology -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor equol -
dc.subject.keywordAuthor intestine inflammation -
dc.subject.keywordAuthor Lactobacillus paracasei JS1 -
dc.subject.keywordAuthor Pueraria lobata -
dc.subject.keywordAuthor skin moisturizing -
dc.subject.keywordPlus IN-VITRO -
dc.subject.keywordPlus CASEI GROUP -
dc.subject.keywordPlus GEN-NOV. -
dc.subject.keywordPlus SOY -
dc.subject.keywordPlus DAIDZEIN -
dc.subject.keywordPlus ISOFLAVONES -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus BACTERIA -
dc.subject.keywordPlus HISTORY -
dc.subject.keywordPlus FOOD -


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.