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DC Field | Value | Language |
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dc.citation.endPage | 419 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 407 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 19 | - |
dc.contributor.author | Manni, Michela | - |
dc.contributor.author | Gupta, Sanjay | - |
dc.contributor.author | Ricker, Edd | - |
dc.contributor.author | Chinenov, Yurii | - |
dc.contributor.author | Park, Sung Ho | - |
dc.contributor.author | Shi, Man | - |
dc.contributor.author | Pannellini, Tania | - |
dc.contributor.author | Jessberger, Rolf | - |
dc.contributor.author | Ivashkiv, Lionel B. | - |
dc.contributor.author | Pernis, Alessandra B. | - |
dc.date.accessioned | 2023-12-21T20:48:15Z | - |
dc.date.available | 2023-12-21T20:48:15Z | - |
dc.date.created | 2019-03-12 | - |
dc.date.issued | 2018-04 | - |
dc.description.abstract | Age-associated B cells (ABCs) are a subset of B cells dependent on the transcription factor T-bet that accumulate prematurely in autoimmune settings. The pathways that regulate ABCs in autoimmunity are largely unknown. SWAP-70 and DEF6 (also known as IBP or SLAT) are the only two members of the SWEF family, a unique family of Rho GTPase-regulatory proteins that control both cytoskeletal dynamics and the activity of the transcription factor IRF4. Notably, DEF6 is a newly identified human risk variant for systemic lupus erythematosus. Here we found that the lupus syndrome that developed in SWEF-deficient mice was accompanied by the accumulation of ABCs that produced autoantibodies after stimulation. ABCs from SWEF-deficient mice exhibited a distinctive transcriptome and a unique chromatin landscape characterized by enrichment for motifs bound by transcription factors of the IRF and AP-1 families and the transcription factor T-bet. Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus. The lack of SWEF proteins led to dysregulated activity of IRF5 in response to stimulation with IL-21. These studies thus elucidate a previously unknown signaling pathway that controls ABCs in autoimmunity. | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.19, no.4, pp.407 - 419 | - |
dc.identifier.doi | 10.1038/s41590-018-0056-8 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.scopusid | 2-s2.0-85042555344 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/26353 | - |
dc.identifier.url | https://www.nature.com/articles/s41590-018-0056-8 | - |
dc.identifier.wosid | 000428151000020 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Regulation of age-associated B cells by IRF5 in systemic autoimmunity | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | FACTOR T-BET | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | SWAP-70-LIKE ADAPTER | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LUPUS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordPlus | INTERLEUKIN-21 | - |
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