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DC Field | Value | Language |
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dc.citation.startPage | 12478 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 7 | - |
dc.contributor.author | Zhang, Zhipeng | - |
dc.contributor.author | Bae, Han Yong | - |
dc.contributor.author | Guin, Joyram | - |
dc.contributor.author | Rabalakos, Constantinos | - |
dc.contributor.author | van Gemmeren, Manuel | - |
dc.contributor.author | Leutzsch, Markus | - |
dc.contributor.author | Klussmann, Martin | - |
dc.contributor.author | List, Benjamin | - |
dc.date.accessioned | 2023-12-21T23:16:15Z | - |
dc.date.available | 2023-12-21T23:16:15Z | - |
dc.date.created | 2019-02-11 | - |
dc.date.issued | 2016-08 | - |
dc.description.abstract | Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organocatalysis proves to be remarkably successful in addressing this problem and enabled a molar-scale cyanosilylation in quantitative yield and with excellent enantioselectivity. Also, the catalyst loading could be lowered to a part-per-million level (50 ppm: 0.005 mol%). A readily accessible chiral disulfonimide was used, which in combination with trimethylsilyl cyanide, turned into the active silylium Lewis acid organocatalyst. The nature of a peculiar phenomenon referred to as a "dormant period'', which is mainly induced by water, was systematically investigated by means of in situ Fourier transform infrared analysis. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.7, pp.12478 | - |
dc.identifier.doi | 10.1038/ncomms12478 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-84983314181 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25869 | - |
dc.identifier.url | https://www.nature.com/articles/ncomms12478 | - |
dc.identifier.wosid | 000381771500001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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