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Takayama, Shuichi
Cell and Microfluidics Lab
Research Interests
  • Bio-MEMS and Microfluidics
  • Bio-Nanotechnology
  • Biofluids
  • Biomaterials
  • Tissue Engineering and Regenerative Medicine.

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Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system

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dc.contributor.author White, Joshua B. ko
dc.contributor.author Takayama, Shuichi ko
dc.date.available 2014-04-09T08:24:04Z -
dc.date.created 2013-06-24 ko
dc.date.issued 2011-09 ko
dc.identifier.citation INTEGRATIVE BIOLOGY, v.3, no.10, pp.1003 - 1010 ko
dc.identifier.issn 1757-9694 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/2585 -
dc.description.abstract This manuscript describes mathematical models that apply an aggregating receptor scheme to the epidermal growth factor receptor (EGFR) system to interpret and predict directed cell migration behaviors in differently-shaped chemoattractant gradients. This method incorporates the latest biochemical insights on ligand-receptor activation kinetics and receptor cooperativity into the commonly used difference in the fractional receptor occupancy (DFRO) model for explaining chemotaxis. The enhanced model derives the functionally more relevant value of difference in fractional receptor activation (DFRA). This DFRA analysis encompasses all features and predictions of the DFRO analyses. Importantly, DFRA analysis can additionally explain in vitro microfluidic chemotaxis experiments that are difficult to explain using only DFRO concepts such as why some cells may migrate well only in a higher concentration regime of exponential chemoattractant gradients. The DFRA analysis also suggests receptor activation strategies that cells may use to tune their responsiveness to differently-shaped in vivo gradients. DFRA analysis is conceptually and computationally straightforward. The results it provides are envisioned to serve as quick semi-quantitative guides to design chemotaxis experiments and to develop hypotheses for interpretation of results from directed cell migration experiments ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher ROYAL SOC CHEMISTRY ko
dc.title Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-80053635683 ko
dc.identifier.wosid 000295580100005 ko
dc.type.rims ART ko
dc.description.wostc 2 *
dc.description.scopustc 2 *
dc.date.tcdate 2015-02-28 *
dc.date.scptcdate 2014-07-12 *
dc.identifier.doi 10.1039/c1ib00040c ko
dc.identifier.url https://academic.oup.com/ib/article/3/10/1003/5214118 ko
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