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DC Field | Value | Language |
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dc.citation.number | 6413 | - |
dc.citation.startPage | 420 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 362 | - |
dc.contributor.author | Corces, M. Ryan | - |
dc.contributor.author | Granja, Jeffrey M. | - |
dc.contributor.author | Shams, Shadi | - |
dc.contributor.author | Louie, Bryan H. | - |
dc.contributor.author | Seoane, Jose A. | - |
dc.contributor.author | Zhou, Wanding | - |
dc.contributor.author | Silva, Tiago C. | - |
dc.contributor.author | Groeneveld, Clarice | - |
dc.contributor.author | Wong, Christopher K. | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Satpathy, Ansuman T. | - |
dc.contributor.author | Mumbach, Maxwell R. | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Sheffield, Nathan C. | - |
dc.contributor.author | Felau, Ina | - |
dc.contributor.author | Castro, Mauro A. A. | - |
dc.contributor.author | Berman, Benjamin P. | - |
dc.contributor.author | Staudt, Louis M. | - |
dc.contributor.author | Zenklusen, Jean C. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Curtis, Christina | - |
dc.contributor.author | Greenleaf, William J. | - |
dc.contributor.author | Chang, Howard Y. | - |
dc.date.accessioned | 2023-12-21T20:08:20Z | - |
dc.date.available | 2023-12-21T20:08:20Z | - |
dc.date.created | 2019-01-18 | - |
dc.date.issued | 2018-10 | - |
dc.description.abstract | We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas (TCGA). We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq (the assay for transposase-accessible chromatin using sequencing) with TCGA multi-omic data identifies a large number of putative distal enhancers that distinguish molecular subtypes of cancers, uncovers specific driving transcription factors via protein-DNA footprints, and nominates long-range gene-regulatory interactions in cancer. These data reveal genetic risk loci of cancer predisposition as active DNA regulatory elements in cancer, identify gene-regulatory interactions underlying cancer immune evasion, and pinpoint noncoding mutations that drive enhancer activation and may affect patient survival. These results suggest a systematic approach to understanding the noncoding genome in cancer to advance diagnosis and therapy. | - |
dc.identifier.bibliographicCitation | SCIENCE, v.362, no.6413, pp.420 | - |
dc.identifier.doi | 10.1126/science.aav1898 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.scopusid | 2-s2.0-85055613174 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25758 | - |
dc.identifier.url | http://science.sciencemag.org/content/362/6413/eaav1898 | - |
dc.identifier.wosid | 000450441900039 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | The chromatin accessibility landscape of primary human cancers | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METHYLOME | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | MOLECULAR CHARACTERIZATION | - |
dc.subject.keywordPlus | CELL DIFFERENTIATION | - |
dc.subject.keywordPlus | ENHANCER | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | REVEALS | - |
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