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DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 2326 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 4 | - |
dc.contributor.author | Gu, Luo | - |
dc.contributor.author | Hall, David J. | - |
dc.contributor.author | Qin, Zhengtao | - |
dc.contributor.author | Anglin, Emily | - |
dc.contributor.author | Joo, Jinmyoung | - |
dc.contributor.author | Mooney, David J. | - |
dc.contributor.author | Howell, Stephen B. | - |
dc.contributor.author | Sailor, Michael J. | - |
dc.date.accessioned | 2023-12-22T03:39:05Z | - |
dc.date.available | 2023-12-22T03:39:05Z | - |
dc.date.created | 2019-01-08 | - |
dc.date.issued | 2013-08 | - |
dc.description.abstract | Fluorescence imaging is one of the most versatile and widely used visualization methods in biomedical research. However, tissue autofluorescence is a major obstacle confounding interpretation of in vivo fluorescence images. The unusually long emission lifetime (5-13 mu s) of photoluminescent porous silicon nanoparticles can allow the time-gated imaging of tissues in vivo, completely eliminating shorter-lived (<10 ns) emission signals from organic chromophores or tissue autofluorescence. Here using a conventional animal imaging system not optimized for such long-lived excited states, we demonstrate improvement of signal to background contrast ratio by 450-fold in vitro and by 420-fold in vivo when imaging porous silicon nanoparticles. Time-gated imaging of porous silicon nanoparticles accumulated in a human ovarian cancer xenograft following intravenous injection is demonstrated in a live mouse. The potential for multiplexing of images in the time domain by using separate porous silicon nanoparticles engineered with different excited state lifetimes is discussed. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.4, pp.2326 | - |
dc.identifier.doi | 10.1038/ncomms3326 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-84883104420 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25698 | - |
dc.identifier.url | https://www.nature.com/articles/ncomms3326 | - |
dc.identifier.wosid | 000323752300011 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MESOPOROUS SILICON | - |
dc.subject.keywordPlus | LIFETIME CONTRAST | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | MICROPARTICLES | - |
dc.subject.keywordPlus | FLUOROPHORES | - |
dc.subject.keywordPlus | TISSUES | - |
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