There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 1 | - |
dc.citation.startPage | e4692 | - |
dc.citation.title | APPLIED ORGANOMETALLIC CHEMISTRY | - |
dc.citation.volume | 33 | - |
dc.contributor.author | Mondal, Ambarish | - |
dc.contributor.author | Tripathy, Rajat K. | - |
dc.contributor.author | Dutta, Parul | - |
dc.contributor.author | Santra, Manas Kumar | - |
dc.contributor.author | Isab, Anvarhusein A. | - |
dc.contributor.author | Bielawski, Christopher W. | - |
dc.contributor.author | Kisan, Hemanta K. | - |
dc.contributor.author | Chandra, Swapan K. | - |
dc.contributor.author | Dinda, Joydev | - |
dc.date.accessioned | 2023-12-21T19:43:30Z | - |
dc.date.available | 2023-12-21T19:43:30Z | - |
dc.date.created | 2019-01-10 | - |
dc.date.issued | 2019-01 | - |
dc.description.abstract | The syntheses, structures, and chemotherapeutic activities of Ag(I)-, Au(I)-, and Ru(II)-complexes ligated to a novel N-heterocyclic carbene ligand, 2-(4-nitrophenyl)imidazo[1,5-a]pyridin-2-ylidene (1), are described. The corresponding complexes, [Ag(1)(2)][PF6], [Au(1)(2)][PF6] (3), and [Ru(1)(p-cymene)Cl][PF6] (4), were prepared using convenient transmetallation chemistry and characterized using a range of spectroscopic and analytical techniques. X-ray crystallography revealed that complexes 2 and 3 adopted linear structures whereas 4 exhibited a prototypical "piano-stool"-like geometry; the structural assignments were further supported by DFT calculations. A series of in vitro studies revealed that while the aforementioned Ag(I), Au(I) and Ru(II) complexes exhibited significant cytotoxicities against the human colon adenocarcinoma (HCT 116), lung cancer (A549), and breast cancer (MCF7) cell lines, the Ru derivative was most prominent. | - |
dc.identifier.bibliographicCitation | APPLIED ORGANOMETALLIC CHEMISTRY, v.33, no.1, pp.e4692 | - |
dc.identifier.doi | 10.1002/aoc.4692 | - |
dc.identifier.issn | 0268-2605 | - |
dc.identifier.scopusid | 2-s2.0-85058036405 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25602 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.4692 | - |
dc.identifier.wosid | 000454321800017 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Ru(II)-based antineoplastic: A "wingtip" N-heterocyclic carbene facilitates access to a new class of organometallics that are cytotoxic to common cancer cell lines | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied; Chemistry, Inorganic & Nuclear | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | Gold(I)-NHC | - |
dc.subject.keywordAuthor | N-heterocyclic carbene | - |
dc.subject.keywordAuthor | silver(I)-NHC | - |
dc.subject.keywordPlus | GOLD(III) COMPLEXES | - |
dc.subject.keywordPlus | RUTHENIUM COMPLEXES | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | AG(I) | - |
dc.subject.keywordPlus | NHC | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SILVER(I) | - |
dc.subject.keywordPlus | AGENTS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.