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Park, Sunghoon
Biochemical Engineering Lab.
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Current status of the metabolic engineering of microorganisms for biohydrogen production

Author(s)
Oh, You-KwanRaj, Subramanian MohanJung, Gyoo YeolPark, Sunghoon
Issued Date
2011-09
DOI
10.1016/j.biortech.2011.04.054
URI
https://scholarworks.unist.ac.kr/handle/201301/25340
Fulltext
https://link.springer.com/article/10.1007%2Fs00253-013-4726-z
Citation
BIORESOURCE TECHNOLOGY, v.102, no.18, pp.8357 - 8367
Abstract
The improvement of H-2 production capabilities of hydrogen (H-2)-producing microorganisms is a challenging issue. Microorganisms have evolved for fast growth and substrate utilization rather than H-2 production. To develop good H-2-producing biocatalysts, many studies have focused on the redirection and/or reconstruction of cellular metabolisms. These studies included the elimination of enzymes and carbon pathways interfering or competing with H-2 production, the incorporation of non-native metabolic pathways leading to H-2 production, the utilization of various carbon substrates, the rectification of H-2-producting enzymes (nitrogenase and hydrogenase) and photophosphorylation systems, and in silico pathway flux analysis, among others. Owing to these studies, significant improvements in the yield and rate of H-2 production, and in the stability of H-2 production activity, were reached. This review presents and discusses the recent developments in biohydrogen production, with a focus on metabolic pathway engineering.
Publisher
ELSEVIER SCI LTD
ISSN
0960-8524
Keyword (Author)
BiohydrogenMetabolic engineeringBiophotolysisPhotofermentationDark fermentation
Keyword
ENHANCED HYDROGEN-PRODUCTIONESCHERICHIA-COLI STRAINSRHODOBACTER-SPHAEROIDESH-2 PRODUCTIONFLUX ANALYSISTHERMOCOCCUS-KODAKARAENSISHYPERTHERMOPHILIC ARCHAEONCHLAMYDOMONAS-REINHARDTIICLOSTRIDIUM-TYROBUTYRICUMENTEROBACTER-AEROGENES

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