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DC Field | Value | Language |
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dc.citation.endPage | 103 | - |
dc.citation.startPage | 97 | - |
dc.citation.title | DYES AND PIGMENTS | - |
dc.citation.volume | 162 | - |
dc.contributor.author | Lee, Misun | - |
dc.contributor.author | Kim, Mingeun | - |
dc.contributor.author | Tikum, Anjong Florence | - |
dc.contributor.author | Lee, Hyuck Jin | - |
dc.contributor.author | Thamilarasan, Vijayan | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.contributor.author | Kim, Jinheung | - |
dc.date.accessioned | 2023-12-21T19:36:51Z | - |
dc.date.available | 2023-12-21T19:36:51Z | - |
dc.date.created | 2018-11-27 | - |
dc.date.issued | 2019-03 | - |
dc.description.abstract | The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of the Alzheimer's disease (AD)-affected brain. Various aggregated Aβ species, including oligomers and fibrils, are generated upon the aggregation process, and these Aβ aggregates have distinct biological properties. To non-invasively monitor the aggregation pathways of Aβ and identify the existence of certain Aβ species in biological environments, an effective strategy to detect Aβ species is necessary. Herein, we report a turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in near-IR fluorescence at ca. 710 nm in the presence of Aβ aggregates in aqueous media. In addition, the fluorescent response of 1 was altered depending on the degree of Aβ aggregation. Moreover, 1 indicates turn-on fluorescence with Aβ aggregates in living cells and is nontoxic under the condition used for live-cell imaging. © 2018 Elsevier Lt | - |
dc.identifier.bibliographicCitation | DYES AND PIGMENTS, v.162, pp.97 - 103 | - |
dc.identifier.doi | 10.1016/j.dyepig.2018.10.013 | - |
dc.identifier.issn | 0143-7208 | - |
dc.identifier.scopusid | 2-s2.0-85054860215 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/25262 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0143720818320874?via%3Dihub | - |
dc.identifier.wosid | 000456226500013 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | A near-infrared fluorescent probe for amyloid-β aggregates | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied; Engineering, Chemical; Materials Science, Textiles | - |
dc.relation.journalResearchArea | Chemistry; Engineering; Materials Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Amyloid-β | - |
dc.subject.keywordAuthor | Benzo[e]indole | - |
dc.subject.keywordAuthor | Dimethylaminostyrene | - |
dc.subject.keywordAuthor | Donor-π-acceptor system | - |
dc.subject.keywordAuthor | Fluorescent probe | - |
dc.subject.keywordPlus | IN-VIVO DETECTION | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | THERAPEUTIC INTERVENTIONS | - |
dc.subject.keywordPlus | MECHANISTIC INSIGHTS | - |
dc.subject.keywordPlus | FLUOROGENIC PROBE | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | THIOFLAVIN-T | - |
dc.subject.keywordPlus | MOUSE-BRAIN | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | OLIGOMERS | - |
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