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DC Field | Value | Language |
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dc.citation.endPage | 1246 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1237 | - |
dc.citation.title | MAGNETIC RESONANCE IN MEDICINE | - |
dc.citation.volume | 81 | - |
dc.contributor.author | Han, SoHyun | - |
dc.contributor.author | Son, Jeong Pyo | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Park, Jang-Yeon | - |
dc.contributor.author | Kim, Seung-Gi | - |
dc.date.accessioned | 2023-12-21T19:39:27Z | - |
dc.date.available | 2023-12-21T19:39:27Z | - |
dc.date.created | 2018-09-06 | - |
dc.date.issued | 2019-02 | - |
dc.description.abstract | Purpose: Sensitivity and specificity of blood oxygenation level-dependent (BOLD) functional MRI (fMRI) is sensitive to magnetic field strength and acquisition methods. We have investigated gradient-echo (GE)- and spin-echo (SE)-BOLD fMRI at ultrahigh fields of 9.4 and 15.2 Tesla (T). Methods: BOLD fMRI experiments responding to forepaw stimulation were performed with 3 echo times (TE) at each echo type and B-0 in alpha-chloralose-anesthetized rats. The contralateral forelimb somatosensory region was selected for quantitative analyses. Results: At 9.4 T and 15.2 T, average baseline T-2* (n = 9) was 26.6 and 17.1 msec, whereas baseline T-2 value (n = 9) was 35.7 and 24.5 msec, respectively. Averaged stimulation-induced Delta R-2* was -1.72 s(-1) at 9.4 T and -3.09 s(-1) at 15.2 T, whereas Delta R-2 was -1.19 s(-1) at 9.4 T and -1.97 s(-1) at 15.2 T. At the optimal TE of tissue T-2* or T-2, BOLD percent changes were slightly higher at 15.2 T than at 9.4 T (GE: 7.4% versus 6.4% and SE: 5.7% versus 5.4%). The Delta R-2(*) and Delta R-2 ratio of 15.2 T to 9.4 T was 1.8 and 1.66, respectively. The ratio of the macrovessel-containing superficial to microvessel-dominant parenchymal BOLD signal was 1.73 to 1.76 for GE-BOLD versus 1.13 to 1.19 for SE-BOLD, indicating that the SE-BOLD contrast is less sensitive to macrovessels than GE-BOLD. Conclusion: SE-BOLD fMRI improves spatial specificity to microvessels compared to GE-BOLD at both fields. BOLD sensitivity is similar at the both fields and can be improved at ultrahigh fields for thermal-noise-dominant ultrahigh-resolution fMRI. |
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dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IN MEDICINE, v.81, no.2, pp.1237 - 1246 | - |
dc.identifier.doi | 10.1002/mrm.27457 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.scopusid | 2-s2.0-85052920763 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24731 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27457 | - |
dc.identifier.wosid | 000462086300043 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Gradient-echo and spin-echo blood oxygenation level-dependent functional MRI at ultrahigh fields of 9.4 and 15.2 Tesla | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | BOLD | - |
dc.subject.keywordAuthor | fMRI | - |
dc.subject.keywordAuthor | gradient-echo | - |
dc.subject.keywordAuthor | spin-echo | - |
dc.subject.keywordAuthor | ultrahigh field | - |
dc.subject.keywordPlus | HUMAN BRAIN | - |
dc.subject.keywordPlus | PHYSIOLOGICAL NOISE | - |
dc.subject.keywordPlus | ALPHA-CHLORALOSE | - |
dc.subject.keywordPlus | SIGNAL CHANGES | - |
dc.subject.keywordPlus | BOLD FMRI | - |
dc.subject.keywordPlus | 7 T | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | FLOW | - |
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