Full metadata record
DC Field | Value | Language |
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dc.citation.number | 3 | - |
dc.citation.startPage | 035008 | - |
dc.citation.title | BIOFABRICATION | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Kang, Donggu | - |
dc.contributor.author | Ahn, Geunseon | - |
dc.contributor.author | Kim, Donghwan | - |
dc.contributor.author | Kang, Hyun-Wook | - |
dc.contributor.author | Yun, Seokhwan | - |
dc.contributor.author | Yun, Won-Soo | - |
dc.contributor.author | Shim, Jin-Hyung | - |
dc.contributor.author | Jin, Songwan | - |
dc.date.accessioned | 2023-12-21T20:37:57Z | - |
dc.date.available | 2023-12-21T20:37:57Z | - |
dc.date.created | 2018-07-07 | - |
dc.date.issued | 2018-07 | - |
dc.description.abstract | Recent advances in three-dimensional bioprinting technology have led to various attempts in fabricating human tissue-like structures. However, current bioprinting technologies have limitations for creating native tissue-like structures. To resolve these issues, we developed a new pre-set extrusion bioprinting technique that can create heterogeneous, multicellular, and multimaterial structures simultaneously. The key to this ability lies in the use of a precursor cartridge that can stably preserve a multimaterial with a pre-defined configuration that can be simply embedded in a syringe-based printer head. The multimaterial can be printed and miniaturized through a micro-nozzle without conspicuous deformation according to the pre-defined configuration of the precursor cartridge. Using this system, we fabricated heterogeneous tissue-like structures such as spinal cords, hepatic lobule, blood vessels, and capillaries. We further obtained a heterogeneous patterned model that embeds HepG2 cells with endothelial cells in a hepatic lobule-like structure. In comparison with homogeneous and heterogeneous cell printing, the heterogeneous patterned model showed a well-organized hepatic lobule structure and higher enzyme activity of CYP3A4. Therefore, this pre-set extrusion bioprinting method could be widely used in the fabrication of a variety of artificial and functional tissues or organs. | - |
dc.identifier.bibliographicCitation | BIOFABRICATION, v.10, no.3, pp.035008 | - |
dc.identifier.doi | 10.1088/1758-5090/aac70b | - |
dc.identifier.issn | 1758-5082 | - |
dc.identifier.scopusid | 2-s2.0-85049932159 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24328 | - |
dc.identifier.url | http://iopscience.iop.org/article/10.1088/1758-5090/aac70b/meta | - |
dc.identifier.wosid | 000434676400001 | - |
dc.language | 영어 | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.title | Pre-set extrusion bioprinting for multiscale heterogeneous tissue structure fabrication | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical; Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Engineering; Materials Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | bioprinting | - |
dc.subject.keywordAuthor | multiscale | - |
dc.subject.keywordAuthor | heterogeneous | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordAuthor | multimaterial | - |
dc.subject.keywordPlus | 3D | - |
dc.subject.keywordPlus | MICROFIBERS | - |
dc.subject.keywordPlus | CONSTRUCTS | - |
dc.subject.keywordPlus | INTEGRITY | - |
dc.subject.keywordPlus | BIOINK | - |
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