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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1223 | - |
dc.citation.number | 6137 | - |
dc.citation.startPage | 1220 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 340 | - |
dc.contributor.author | Chang, Roger L. | - |
dc.contributor.author | Andrews, Kathleen | - |
dc.contributor.author | Kim, Donghyuk | - |
dc.contributor.author | Li, Zhanwen | - |
dc.contributor.author | Godzik, Adam | - |
dc.contributor.author | Palsson, Bernhard O. | - |
dc.date.accessioned | 2023-12-22T03:44:24Z | - |
dc.date.available | 2023-12-22T03:44:24Z | - |
dc.date.created | 2018-07-04 | - |
dc.date.issued | 2013-06 | - |
dc.description.abstract | Genome-scale network reconstruction has enabled predictive modeling of metabolism for many systems. Traditionally, protein structural information has not been represented in such reconstructions. Expansion of a genome-scale model of Escherichia coli metabolism by including experimental and predicted protein structures enabled the analysis of protein thermostability in a network context. This analysis allowed the prediction of protein activities that limit network function at superoptimal temperatures and mechanistic interpretations of mutations found in strains adapted to heat. Predicted growth-limiting factors for thermotolerance were validated through nutrient supplementation experiments and defined metabolic sensitivities to heat stress, providing evidence that metabolic enzyme thermostability is rate-limiting at superoptimal temperatures. Inclusion of structural information expanded the content and predictive capability of genome-scale metabolic networks that enable structural systems biology of metabolism. | - |
dc.identifier.bibliographicCitation | SCIENCE, v.340, no.6137, pp.1220 - 1223 | - |
dc.identifier.doi | 10.1126/science.1234012 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.scopusid | 2-s2.0-84878756325 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24289 | - |
dc.identifier.url | http://science.sciencemag.org/content/340/6137/1220 | - |
dc.identifier.wosid | 000319972800047 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Structural Systems Biology Evaluation of Metabolic Thermotolerance in Escherichia coli | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | RECONSTRUCTION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | K-12 | - |
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