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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1299 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1289 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 12 | - |
dc.contributor.author | Seo, Sang Woo | - |
dc.contributor.author | Kim, Donghyuk | - |
dc.contributor.author | Szubin, Richard | - |
dc.contributor.author | Palsson, Bernhard O. | - |
dc.date.accessioned | 2023-12-22T00:47:58Z | - |
dc.date.available | 2023-12-22T00:47:58Z | - |
dc.date.created | 2018-07-04 | - |
dc.date.issued | 2015-08 | - |
dc.description.abstract | Three transcription factors (TFs), OxyR, SoxR, and SoxS, play a critical role in transcriptional regulation of the defense system for oxidative stress in bacteria. However, their full genome-wide regulatory potential is unknown. Here, we perform a genome-scale reconstruction of the OxyR, SoxR, and SoxS regulons in Escherichia coli K-12 MG1655. Integrative data analysis reveals that a total of 68 genes in 51 transcription units (TUs) belong to these regulons. Among them, 48 genes showed more than 2-fold changes in expression level under single-TF-knockout conditions. This reconstruction expands the genome-wide roles of these factors to include direct activation of genes related to amino acid biosynthesis (methionine and aromatic amino acids), cell wall synthesis (lipid A biosynthesis and peptidoglycan growth), and divalent metal ion transport (Mn2+, Zn2+, and Mg2+). Investigating the co-regulation of these genes with other stress-response TFs reveals that they are independently regulated by stress-specific TFs. | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.12, no.8, pp.1289 - 1299 | - |
dc.identifier.doi | 10.1016/j.celrep.2015.07.043 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.scopusid | 2-s2.0-84939798405 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24283 | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S2211124715008190 | - |
dc.identifier.wosid | 000360182200008 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655 | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SUPEROXIDE STRESS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | SCALE RECONSTRUCTION | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | METABOLISM | - |
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