There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | E4632 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | E4623 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 115 | - |
dc.contributor.author | Kim, Kyu Min | - |
dc.contributor.author | Wijerathne, Tharaka | - |
dc.contributor.author | Hur, Jin-Hoe | - |
dc.contributor.author | Kang, Uk Jung | - |
dc.contributor.author | Kim, Ihn Hyeong | - |
dc.contributor.author | Kweon, Yeong Cheon | - |
dc.contributor.author | Lee, Ah Reum | - |
dc.contributor.author | Jeong, Su Ji | - |
dc.contributor.author | Lee, Sang Kwon | - |
dc.contributor.author | Lee, Yoon Young | - |
dc.contributor.author | Sim, Bo-Woong | - |
dc.contributor.author | Lee, Jong-Hee | - |
dc.contributor.author | Baig, Chunggi | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Chang, Kyu-Tae | - |
dc.contributor.author | Lee, Kyu Pil | - |
dc.contributor.author | Park, Chan Young | - |
dc.date.accessioned | 2023-12-21T20:44:51Z | - |
dc.date.available | 2023-12-21T20:44:51Z | - |
dc.date.created | 2018-06-09 | - |
dc.date.issued | 2018-05 | - |
dc.description.abstract | Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai channels in the plasma membrane. This inside-out mechanism of Ca2+ signaling raises an interesting question about the evolution of SOCE: How did these two proteins existing in different cellular compartments evolve to interact with each other? We investigated the gating mechanism of Caenorhabditis elegans Orai channels. Our analysis revealed a mechanism of Orai gating by STIM binding to the intracellular 2-3 loop of Orai in C. elegans that is radically different from Orai gating by STIM binding to the N and C termini of Orai in mammals. In addition, we found that the conserved hydrophobic amino acids in the 2-3 loop of Orai1 are important for the oligomerization and gating of channels and are regulated via an intramolecular interaction mechanism mediated by the N and C termini of Orai1. This study identifies a previously unknown SOCE mechanism in C. elegans and suggests that, while the STIM-Orai interaction is conserved between invertebrates and mammals, the gating mechanism for Orai channels differs considerably. | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.115, no.20, pp.E4623 - E4632 | - |
dc.identifier.doi | 10.1073/pnas.1714986115 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.scopusid | 2-s2.0-85046940827 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24214 | - |
dc.identifier.url | http://www.pnas.org/content/115/20/E4623 | - |
dc.identifier.wosid | 000432120400013 | - |
dc.language | 영어 | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Ca2+ signaling | - |
dc.subject.keywordAuthor | STIM1 | - |
dc.subject.keywordAuthor | Orai1 | - |
dc.subject.keywordAuthor | SOCE | - |
dc.subject.keywordAuthor | Caenorhabditis elegans | - |
dc.subject.keywordPlus | OPERATED CALCIUM-CHANNELS | - |
dc.subject.keywordPlus | ACTIVATES CRAC CHANNELS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | ION SELECTIVITY | - |
dc.subject.keywordPlus | CA2+ SENSOR | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | STORE | - |
dc.subject.keywordPlus | PORE | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | CELLS | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.