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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;

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MCU Interacts with Mirol to Modulate Mitochondrial Functions In Neurons

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Title
MCU Interacts with Mirol to Modulate Mitochondrial Functions In Neurons
Author
Niescier, Robert F.Hong, KidoPark, DongkeunMin, Kyung-Tai
Issue Date
2018-05
Publisher
SOC NEUROSCIENCE
Citation
JOURNAL OF NEUROSCIENCE, v.38, no.20, pp.4666 - 4677
Abstract
Mitochondrial Ca2+ uptake is gated by the mitochondrial calcium uniplex, which is comprised of mitochondrial calcium uniporter (MCU), the Ca2+ pore-forming subunit of the complex, and its regulators. Ca2+ influx through MCU affects both mitochondrial function and movement in neurons, but its direct role in mitochondrial movement has not been explored. In this report, we show a link between MCU and Miro1, a membrane protein known to regulate mitochondrial movement. We find that MCU interacts with Miro1 through MCU's N-terminal domain, previously thought to be the mitochondrial targeting sequence. Our results show that the N-terminus of MCU has a transmembrane domain that traverses the outer mitochondrial membrane, which is dispensable for MCU localization into mitochondria. However, this domain is required for Miro1 interaction and is critical for Miro1 directed movement. Together, our findings reveal Miro1 as a new component of the MCU complex, and that MCU is an important regulator of mitochondrial transport.
URI
https://scholarworks.unist.ac.kr/handle/201301/24048
URL
http://www.jneurosci.org/content/38/20/4666
DOI
10.1523/JNEUROSCI.0504-18.2018
ISSN
0270-6474
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