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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

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Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins

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dc.contributor.author Park, Haeree ko
dc.contributor.author Choi, Yeongkyu ko
dc.contributor.author Jeena, M. T. ko
dc.contributor.author Ahn, Eungjin ko
dc.contributor.author Choi, Yuri ko
dc.contributor.author Kang, Myeong-Gyun ko
dc.contributor.author Lee, Chae Gyu ko
dc.contributor.author Kwon, Tae-Hyuk ko
dc.contributor.author Rhee, Hyun-Woo ko
dc.contributor.author Ryu, Ja-Hyoung ko
dc.contributor.author Kim, Byeong-Su ko
dc.date.available 2018-05-04T00:49:12Z -
dc.date.created 2018-04-24 ko
dc.date.issued 2018-04 ko
dc.identifier.citation MACROMOLECULAR BIOSCIENCE, v.18, no.4, pp.1700356 ko
dc.identifier.issn 1616-5187 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/24024 -
dc.description.abstract Owing to the unique advantages of combining the characteristics of hydrogels and nanoparticles, nanogels are actively investigated as a promising platform for advanced biomedical applications. In this work, a self-cross-linked hyperbranched polyglycerol nanogel is synthesized using the thiol-disulfide exchange reaction based on a novel disulfide-containing polymer. A series of structural analyses confirm the tunable size and cross-linking density depending on the type of polymer (homo- or copolymer) and the amount of reducing agent, dithiothreitol, used in the preparation of the nanogels. The nanogels retain not only small molecular therapeutics irrespective of hydrophilic and hydrophobic nature but also large enzymes such as beta-galactosidase by exploiting the self-cross-linking chemistry. Their superior biocompatibility together with the controllable release of active therapeutic agents suggests the applicability of nanogels in smart drug delivery systems. ko
dc.language 영어 ko
dc.publisher WILEY-V C H VERLAG GMBH ko
dc.title Reduction-Triggered Self-Cross-Linked Hyperbranched Polyglycerol Nanogels for Intracellular Delivery of Drugs and Proteins ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85045521958 ko
dc.identifier.wosid 000430395900005 ko
dc.type.rims ART ko
dc.identifier.doi 10.1002/mabi.201700356 ko
dc.identifier.url https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201700356 ko
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