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DC Field | Value | Language |
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dc.citation.endPage | 217 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 211 | - |
dc.citation.title | BRAIN & DEVELOPMENT | - |
dc.citation.volume | 40 | - |
dc.contributor.author | Lee, Kyung Yeon | - |
dc.contributor.author | Moon, Chang Hoon | - |
dc.contributor.author | Choi, Seong Hoon | - |
dc.date.accessioned | 2023-12-21T21:07:39Z | - |
dc.date.available | 2023-12-21T21:07:39Z | - |
dc.date.created | 2018-03-22 | - |
dc.date.issued | 2018-03 | - |
dc.description.abstract | Objective: The purpose of this study was to identify whether there is an increase in type I interferon and proinflammatory cytokine levels in the cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy. Methods: Levels of type I interferons (interferon-alpha and interferon-beta) and proinflammatory cytokines (interleukin-6 and interferon-gamma) were measured in the cerebrospinal fluid of 23 newborns with rotavirus-associated leukoencephalopathy (patient group) and 39 infants under 90 days-of-age (control group). Results: Cerebrospinal fluid pleocytosis was not observed in either group. Cerebrospinal fluid interleukin-6 levels were significantly higher in the patient group (7.02 +/- 5.88 pg/mL) than in the control group (1.14 +/- 1.90 pg/mL) (p <.0001). The mean cerebrospinal fluid interferon-gamma levels of the patient group (24.43 +/- 40.16 pg/mL) were also significantly higher than those of the controls group (0.0 +/- 0.0 pg/mL) (p <.0001). Cerebrospinal fluid interferon-alpha was not detected in any patient (0%) from the patient group, but was detected in four (10.3%) of the controls. Interferon-beta was detected in only two patients (8.7%) from the patient group and in one (2.6%) of the controls. Cerebrospinal fluid interleukin-6 levels correlated positively with the extent of white matter lesions on diffusion-weighted magnetic resonance imaging (r = 0.607, p=.002). Conclusions: Significant increases in proinflammatory cytokine levels accompanied by very low detection rates of type I interferon in cerebrospinal fluid indicate that rotavirus-associated leukoencephalopathy in newborns can be correlated with central nervous system inflammatory processes without direct virus invasion into the central nervous system. (C) 2017 The Japanese Society of Child Neurology. | - |
dc.identifier.bibliographicCitation | BRAIN & DEVELOPMENT, v.40, no.3, pp.211 - 217 | - |
dc.identifier.doi | 10.1016/j.braindev.2017.10.006 | - |
dc.identifier.issn | 0387-7604 | - |
dc.identifier.scopusid | 2-s2.0-85035142568 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/23864 | - |
dc.identifier.url | http://www.brainanddevelopment.com/article/S0387-7604(17)30272-3/fulltext | - |
dc.identifier.wosid | 000426533600007 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Type I interferon and proinflammatory cytokine levels in cerebrospinal fluid of newborns with rotavirus-associated leukoencephalopathy | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Leukoencephalopathy | - |
dc.subject.keywordAuthor | Rotavirus | - |
dc.subject.keywordAuthor | Newborn | - |
dc.subject.keywordAuthor | Cerebrospinal fluid | - |
dc.subject.keywordAuthor | Type 1 interferon | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
dc.subject.keywordPlus | WHITE-MATTER INJURY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | ADULTS | - |
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