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Kim, Jiyun
School of Materials Science and Engineering
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Liquid-capped encoded microcapsules for multiplex assay

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Title
Liquid-capped encoded microcapsules for multiplex assay
Author
Song, YounghoonJeong, YunjinKwon, TaehongLee, DaewonOh, Dong YoonPark, Tae-JoonKim, JunhoiKim, JiyunKwon, Sunghoon
Issue Date
2017-02
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.17, no.3, pp.429 - 437
Abstract
Although droplet microfludics is a promising technology for handling a number of liquids of a single type of analyte, it has limitations in handling thousands of different types of analytes for multiplex assay. Here, we present a novel “liquid-capped encoded microcapsule”, which is applicable to various liquid format assays. Various liquid drops can be graphically encoded and arrayed without repeated dispensing processes, evaporation, and the risk of cross-contamination. Millions of nanoliter-scale liquids are encapsulated within encoded microcapsules and self-assembled in microwells in a single dispensing process. The graphical code on the microcapsule enables identification of randomly assembled microcapsules in each microwell. We conducted various liquid phase assays including enzyme inhibitor screening, virus transduction, and drug-induced apoptosis tests. The results showed that our liquid handling technology can be utilized widely for various solution phase assays.
URI
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DOI
10.1039/C6LC01268J
ISSN
1473-0197
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