There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 991 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 983 | - |
dc.citation.title | KOREAN JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 18 | - |
dc.contributor.author | Park, Ji Eun | - |
dc.contributor.author | Park, Bumwoo | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Kim, Ho Sung | - |
dc.contributor.author | Choi, Choong Gon | - |
dc.contributor.author | Jung, Seung Chai | - |
dc.contributor.author | Oh, Joo Young | - |
dc.contributor.author | Lee, Jae-Hong | - |
dc.contributor.author | Roh, Jee Hoon | - |
dc.contributor.author | Shim, Woo Hyun | - |
dc.date.accessioned | 2023-12-21T21:38:33Z | - |
dc.date.available | 2023-12-21T21:38:33Z | - |
dc.date.created | 2017-11-07 | - |
dc.date.issued | 2017-11 | - |
dc.description.abstract | Objective: To identify potential imaging biomarkers of Alzheimer’s disease by combining brain cortical thickness (CThk) and functional connectivity and to validate this model’s diagnostic accuracy in a validation set. Materials and Methods: Data from 98 subjects was retrospectively reviewed, including a study set (n = 63) and a validation set from the Alzheimer’s Disease Neuroimaging Initiative (n = 35). From each subject, data for CThk and functional connectivity of the default mode network was extracted from structural T1-weighted and resting-state functional magnetic resonance imaging. Cortical regions with significant differences between patients and healthy controls in the correlation of CThk and functional connectivity were identified in the study set. The diagnostic accuracy of functional connectivity measures combined with CThk in the identified regions was evaluated against that in the medial temporal lobes using the validation set and application of a support vector machine. Results: Group-wise differences in the correlation of CThk and default mode network functional connectivity were identified in the superior temporal (p < 0.001) and supramarginal gyrus (p = 0.007) of the left cerebral hemisphere. Default mode network functional connectivity combined with the CThk of those two regions were more accurate than that combined with the CThk of both medial temporal lobes (91.7% vs. 75%). Conclusion: Combining functional information with CThk of the superior temporal and supramarginal gyri in the left cerebral hemisphere improves diagnostic accuracy, making it a potential imaging biomarker for Alzheimer’s disease. | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, v.18, no.6, pp.983 - 991 | - |
dc.identifier.doi | 10.3348/kjr.2017.18.6.983 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.scopusid | 2-s2.0-85031311921 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22908 | - |
dc.identifier.url | https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2017.18.6.983 | - |
dc.identifier.wosid | 000415617100013 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN RADIOLOGICAL SOC | - |
dc.title | Improved diagnostic accuracy of alzheimer’s disease by combining regional cortical thickness and default mode network functional connectivity: Validated in the alzheimer’s disease neuroimaging initiative set | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Alzheimer’s disease | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Brain | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Resting-state functional MRI | - |
dc.subject.keywordPlus | SUPPORT VECTOR MACHINES | - |
dc.subject.keywordPlus | COGNITIVE DECLINE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DISCONNECTION | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | SUBREGIONS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | MRI | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.