There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 7281 | - |
dc.citation.number | 29 | - |
dc.citation.startPage | 7272 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.contributor.author | Kang, Bitna | - |
dc.contributor.author | Kim, You-Kyoung | - |
dc.contributor.author | Zhang, Qiankun | - |
dc.contributor.author | Lee, Won-Seok | - |
dc.contributor.author | Islam, Mohammad Ariful | - |
dc.contributor.author | Kang, Sang-Kee | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Choi, Yun-Jaie | - |
dc.contributor.author | Cho, Chong-Su | - |
dc.date.accessioned | 2023-12-22T04:39:11Z | - |
dc.date.available | 2023-12-22T04:39:11Z | - |
dc.date.created | 2017-09-01 | - |
dc.date.issued | 2012-10 | - |
dc.description.abstract | Controlling the cellular uptake mechanism and consequent intracellular route of polyplexes is important to improve the transfection efficiency of the non-viral gene delivery. Here, we report a new non-viral vector, polymannitol-based gene transporter (PMT), generated by crosslinking low molecular weight polyethylenimine with mannitol diacrylate, which has low cytotoxicity and good transfection efficiency. Interestingly, the uptake pathway of PMT/DNA complexes was shifted into caveolae-mediated endocytosis, avoiding lysosomal degradation. The mechanism of increased caveolae-mediated endocytosis of PMT/DNA complexes was found to be correlated with mechanosensing signal transduction by the hyperosmotic polymannitol part. Our results suggested that PMT, polymannitol-based gene transporter, is a safe and efficient gene delivery system with a well-modulated uptake pathway and intracellular route for gene therapy. | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.29, pp.7272 - 7281 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2012.06.037 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.scopusid | 2-s2.0-84864312908 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22627 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961212006874?via%3Dihub | - |
dc.identifier.wosid | 000308269600036 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Selective stimulation of caveolae-mediated endocytosis by an osmotic polymannitol-based gene transporter | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Gene delivery | - |
dc.subject.keywordAuthor | Caveolae-mediated endocytosis | - |
dc.subject.keywordAuthor | Polyethylenimine | - |
dc.subject.keywordAuthor | Polymannitol | - |
dc.subject.keywordAuthor | Hyperosmotic stress | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CLATHRIN | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | INTERNALIZATION | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.