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DC Field | Value | Language |
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dc.citation.endPage | 6705 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6695 | - |
dc.citation.title | INORGANIC CHEMISTRY | - |
dc.citation.volume | 56 | - |
dc.contributor.author | Ji, Yonghwan | - |
dc.contributor.author | Lee, Hyuck Jin | - |
dc.contributor.author | Kim, Munjeong | - |
dc.contributor.author | Nam, Geewoo | - |
dc.contributor.author | Lee, Shun Jung C. | - |
dc.contributor.author | Cho. Jaeheung | - |
dc.contributor.author | Park, Cheol-Min | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.date.accessioned | 2023-12-21T22:11:49Z | - |
dc.date.available | 2023-12-21T22:11:49Z | - |
dc.date.created | 2017-06-01 | - |
dc.date.issued | 2017-06 | - |
dc.description.abstract | The complexity of Alzheimer’s disease (AD) stems from the inter-relation of multiple pathological factors upon initiation and progression of the disease. To identify the involvement of metal-bound amyloid-β (metal-Aβ) aggregation in AD pathology, among the pathogenic features found in the AD-affected brain, small molecules as chemical tools capable of controlling metal-Aβ aggregation were developed. Herein, we report a new class of 2,2′-bipyridine (bpy) derivatives (1-4) rationally designed to be chemical modulators toward metal-Aβ aggregation over metal-free Aβ analogue. The bpy derivatives were constructed through a rational design strategy employing straightforward structural variations onto the backbone of a metal chelator, bpy: (i) incorporation of an Aβ interacting moiety; (ii) introduction of a methyl group at different positions. The newly prepared bpy derivatives were observed to bind to metal ions [i.e., Cu(II) and Zn(II)] and interact with metal-Aβ over metal-free Aβ to varying degrees. Distinguishable from bpy, the bpy derivatives (1-3) were indicated to noticeably modulate the aggregation pathways of Cu(II)-Aβ and Zn(II)-Aβ over metal-free Aβ. Overall, our studies of the bpy derivatives demonstrate that the alteration of metal binding properties as well as the installation of an Aβ interacting capability onto a metal chelating framework, devised via the rational structure-based design, were able to achieve evident modulating reactivity against metal-Aβ aggregation. Obviating the need for complicated structures, our design approach, presented in this work, could be appropriately utilized for inventing small molecules as chemical tools for studying desired metal-related targets in biological systems. | - |
dc.identifier.bibliographicCitation | INORGANIC CHEMISTRY, v.56, no.11, pp.6695 - 6705 | - |
dc.identifier.doi | 10.1021/acs.inorgchem.7b00782 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.scopusid | 2-s2.0-85020272501 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/22010 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/acs.inorgchem.7b00782 | - |
dc.identifier.wosid | 000402950600073 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Strategic Design of 2,2 '-Bipyridine Derivatives to Modulate Metal Amyloid-beta Aggregation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SMALL MOLECULES | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | 2,2&apos | - |
dc.subject.keywordPlus | -DIPYRIDYL | - |
dc.subject.keywordPlus | COORDINATION | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
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